Products Description
L-Leucine is an indispensable essential branched-chain amino acid (BCAA) that cannot be biosynthesized by the human body and must be supplemented exogenously. Biochemically, it acts as both a protein synthesis substrate and a key intracellular signaling molecule. It mediates cellular uptake via LAT1 transporter, binds to Sestrin2 protein to trigger mTORC1 pathway activation, upregulates the phosphorylation of S6K1 and 4E-BP1, and accelerates mRNA translation to promote skeletal muscle protein synthesis. Meanwhile, it inhibits the ubiquitin-proteasome pathway and autophagy, reducing muscle protein degradation. Metabolically, L-Leucine is degraded into acetyl-CoA and acetoacetate, participating in ketogenesis and energy supply for cell metabolism. It features stable molecular structure, rapid gastrointestinal dissolution and absorption, high water solubility, and complies with global pharmacopoeia standard detection indicators, suitable for standardized formulation and industrial processing.
Technical Specification
| Test Item | CP2020 Standard | EP11 Standard | USP2023 Standard | AJI92 Standard |
|---|---|---|---|---|
| Assay Content | ≥98.5% | 98.5%-101.0% | 98.5%-101.5% | 99.0%-100.5% |
| Acidity (pH) | 5.5-6.5 | - | 5.5-7.0 | 5.5-6.5 |
| Specific Rotation [α]D20 | +14.9°~+16.0° | +14.5°~+16.5° | - | +14.9°~+16.0° |
| Light Transmission | ≥98.0% | - | - | ≥98.0% |
| Chloride | ≤0.02% | ≤0.02% | ≤0.05% | ≤0.02% |
| Ammonium Salt | ≤0.02% | ≤0.02% | - | ≤0.02% |
| Sulfate | ≤0.02% | ≤0.03% | ≤0.03% | ≤0.02% |
| Iron Salt | ≤10PPM | ≤10PPM | ≤30PPM | ≤10PPM |
| Heavy Metal | ≤10PPM | - | - | ≤10PPM |
| Arsenic Salt | ≤1PPM | - | - | ≤1PPM |
| Other Amino Acids | ≤0.5% | - | Total Impurities ≤2.0% | Complies |
| Loss on Drying | ≤0.20% | ≤0.50% | ≤0.2% | ≤0.20% |
| Residue on Ignition | ≤0.10% | ≤0.10% | ≤0.4% | ≤0.10% |
| Total Plate Count | ≤500 CFU/g | ≤500 CFU/g | ≤500 CFU/g | ≤500 CFU/g |
| Mold & Yeast | ≤50 CFU/g | ≤50 CFU/g | ≤50 CFU/g | ≤50 CFU/g |
Safety Profile
- Toxicity Grade：Low toxicity, non-irritating to human skin, eyes and respiratory tract; non-skin sensitizer.
- Safety Classification：Not classified as hazardous substance per GHS standard; WGK 1 (slight water pollution grade).
- Oral Tolerance：Normal adults tolerate oral intake below 10g/day without adverse reactions; long-term safe supplementary dose ≤35g/day.
- Crowd Restriction：Not recommended for patients with diabetes, cerebral arteriosclerosis, renal diseases with proteinuria and duodenal ulcer.
- Storage Stability：Stable under normal temperature and dry environment; avoid high humidity, high temperature and direct sunlight to prevent agglomeration and efficacy decline.
- Safety Certificates：Available with COA, SDS, ISO22000, HALAL, KOSHER, Food Grade Production License; batch inspection reports provided for each order.
- Residue Control：Heavy metals, arsenic, microbial indicators all meet EU and US food/pharma grade limit standards.
Applications
- Nutritional Supplement：Sports nutrition powder, BCAA compound formula, muscle gain and post-exercise recovery supplements, elderly sarcopenia nutritional preparations.
- Food Additive：Used as nutritional fortifier in dairy products, baked goods, functional beverages, infant formula (dosage complies with GB2760 and FDA regulations).
- Pharmaceutical Raw Materials：Parenteral nutrition injection, oral tablet excipient, amino acid compound preparation, medical enteral nutrition formula.
- Cosmetic Raw Materials：Skin moisturizing and anti-aging cosmetics, used as skin cell metabolism regulator (added within cosmetic allowed dosage limit).
- Feed Additive：Animal nutritional fortifier, livestock and poultry growth promotion raw material, allowed for adding in compound feed.
Restricted & Prohibited Use
- Prohibited for direct intravenous injection exceeding safe dose without medical guidance.
- Not allowed to be used as raw material for weight-loss drugs and hormone preparations in violation of regulations.
- Cosmetic use shall not exceed the maximum addition limit specified by EU Cosmetics Regulation.
- Not applicable for industrial chemical synthesis beyond food/pharma/feed/cosmetic approved scope.
- For laboratory research use only, cannot be directly used as household daily chemical raw materials.
Why Choose Us
- Multi-Pharmacopoeia Compliance：Support CP2020/EP11/USP2023/AJI92 four international standards, meet global market access requirements.
- High Purity & Strict Control：Purity up to 99.0%-100.5%, strict control of heavy metals, microbes and impurity indicators, no filler addition.
- Stable Supply Capacity：Fermentation production process, annual output over 5000 tons, sufficient inventory to support bulk order and customized packaging.
- Complete Certification System：Ready to provide COA, SDS, ISO, HALAL, KOSHER and other certificates, support customs clearance in Europe, America, Southeast Asia.
- Professional Customization：Support 1kg/bag, 25kg/drum standard packaging, and provide customized mesh size, label and formula compounding service.
- Fast Global Delivery：Express/air/sea three logistics solutions, 7 days lead time, door-to-door and port-to-port service available.
- Professional Technical Support：Provide product mechanism documentation, application formula guidance and safety compliance consultation for free.
Delivery & Shipping Service
Storage: Store in a dry, cool, and well-ventilated place.
Packaging: 1 kg/bag, 25 kg/drum
Delivery Time: 7 days after order placement
1.Express Delivery
3-5 days for shipments under 100 kg
Door-to-door service
2.Ocean Freight
Over 300 kg: Approximately 30 days. Port-to-port service requires a professional customs clearance agent.
3.Air Freight
100kg-1000kg, 5-7 days
Airport-to-airport service, requires a professional customs clearance agent
Frequently Asked Questions
What are the main functions of L-Leucine?
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It activates mTORC1 pathway to promote muscle protein synthesis, inhibit protein decomposition, regulate cell metabolism and provide energy supply.
What packaging do you provide?
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Standard packaging is 1kg/bag and 25kg/drum; customized packaging is acceptable upon request.
How about your delivery time?
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Sample order 3-5 days, bulk order 7 days after payment; sea freight takes about 30 days, air freight 5-7 days.
Can you provide safety and quality certificates?
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Yes, we can provide COA, SDS, ISO22000, HALAL, KOSHER and batch inspection reports.
What is the storage method of L-Leucine powder?
-
What is the storage method of L-Leucine powder?
Send inquiry or contact us to get free sample, and learn more details about it.
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