Products Description
Palmitoyl Pentapeptide‑3, widely known under the trade name Matrixyl, is a well‑documented lipophilic signal peptide favored by cosmetic formulators targeting mature and photo‑aged skin. This lipopeptide is constructed by grafting palmitic acid onto the KTTKS five‑amino‑acid sequence, significantly boosting lipid solubility and dermal penetration compared with conventional water‑only peptides.
With CAS registry number 623172‑56‑5, molecular formula C₃₉H₇₅N₇O₁₀ and molecular weight 802.05, our raw material presents fine crystalline white powder with minimal residual impurities. It complies with CosIng inventory listing, FDA cosmetic ingredient guidelines and EU REACH regulatory requirements for global cosmetic manufacturing.
Unlike neurotransmitter‑modulating anti‑wrinkle peptides, Matrixyl works as a cell‑communicating signal molecule. It imitates native TSP‑1 protein to trigger TGF‑β biological responses inside dermal fibroblasts, encouraging skin cells to rebuild key extracellular matrix components including type I, III, IV collagen and elastin. Independent in‑vitro trials and clinical assessments confirm its capacity to lift collagen production, hyaluronic acid output and collagen IV content, helping replenish structural substances depleted throughout skin aging.
Our strictly controlled production workflow keeps batch‑to‑batch variation low, making this peptide powder suitable for high‑end serums, creams and lotion systems for worldwide cosmetic brands.
Technical Specification
|
Item |
Specification |
|---|---|
|
Product Name |
Palmitoyl Pentapeptide-3 (Matrixyl) |
|
CAS Number |
623172-56-5 |
|
Molecular Formula |
C₃₉H₇₅N₇O₁₀ |
|
Molecular Weight |
802.05 |
|
Appearance |
Pure White Fine Powder |
|
Purity |
≥98% (HPLC) |
|
Recommended Dosage |
0.05% - 0.2% for cosmetic formulation |
|
Storage Condition |
Sealed, cool and dry place; room temperature storage, inert atmosphere for long-term preservation |
|
Packaging Specification |
1kg/aluminum foil bag, 25kg/fiber drum |
|
Compliance Standard |
FDA, CosIng, EU REACH Compliant |
Professional Certifications
All our Palmitoyl Pentapeptide-3 raw materials are produced and inspected under strict quality management systems. We hold complete authoritative certifications to guarantee product safety, stability and compliance for global cosmetic trade and formulation application.
- ISO9001 Quality Management System Certification – Ensures standardized production, stable quality control and standardized enterprise management.
- COA & TDS & SDS Official Documents – Batch-wise test reports provided, including purity, heavy metal, microorganism and safety data.
- EU REACH & CosIng Compliance – Registered and compliant with European cosmetic raw material regulations, available for EU market sales.
- FDA Safety Compliance – Meets US cosmetic ingredient safety standards, safe for daily skincare formulation.
- Third-party Authority Testing Report – Support SGS and other third-party testing to support customer market inspection.
Application
1. Anti‑Aging & Dermal Density Improvement
Palmitoyl Pentapeptide‑3 sends biological signals to dermal fibroblast cells to synthesize collagen and elastin. Continuous incorporation within finished formulas helps thicken dermal connective tissue, enhance skin density, relieve sagging appearance, refine enlarged pores and restore plumpness for dull, flattened skin. Ideal for firming serums, lifting day‑night creams, anti‑aging facial lotions.
2. Smoothing Fine Lines & Expression Wrinkles
While classified as a collagen‑signal peptide, it also moderately modulates acetylcholine release to ease repeated facial muscle contraction. It softens crow's feet, forehead creases and nasolabial folds via gentle biological pathways. It serves as a skin‑friendly alternative for brands avoiding strong neuro‑relaxing peptides, perfectly suited for sensitive‑skin anti‑wrinkle formulations.
3. Skin Barrier Rehabilitation & Moisturizing Support
This peptide can modulate EGF‑related epidermal renewal pathways, optimizing stratum corneum lipid arrangement and accelerating epidermal cell turnover. It helps ease dryness, flaking and mild redness triggered by barrier impairment, strengthening skin long‑term moisture retention capacity. Recommended for barrier‑repair moisturizer and sensitive‑care skincare lines.
4. Formulation Compatibility Tips
Best incorporated into water‑alcohol or emulsion systems at temperature below 45℃ to retain peptide bioactivity. Avoid direct blending with high‑concentration strong acids or oxidizing raw materials which may degrade peptide potency. Works synergistically with copper peptides, hyaluronic acid and plant‑derived antioxidants for multi‑target anti‑aging complexes.
Why Choose Us
We act as direct factory supplier for high‑purity Palmitoyl Pentapeptide‑3 Matrixyl powder, supplying cosmetic enterprises across continents with stable peptide raw materials, formulation consultation and cost‑effective bulk supply solutions.
✅ Rigorous impurity control: Heavy‑metal and microbiology testing executed for every production batch, matching FDA, CosIng and EU REACH cosmetic raw‑material requirements. Full set of technical documents including COA, TDS and SDS supplied per shipment.
✅ Flexible order threshold & steady inventory: Year‑round stock maintained. Support lab‑scale free sample provision, small trial batch orders and large‑volume wholesale projects.
✅ Custom R&D technical guidance: Our cosmetic R&D team provides free dosage guidance, ingredient compatibility advice and formulation troubleshooting for your product development.
✅ Factory‑direct pricing mechanism: No intermediate traders. We offer competitive wholesale quotations and adjustable service packages for brand‑specific demands.
✅ Diversified global shipment solutions: Multiple logistics modes including express courier, air freight and sea freight. Complete tracking service for international shipments, covering customs‑related documentation support.
OEM Service Process
We support professional OEM customization services for Palmitoyl Pentapeptide-3 (Matrixyl) cosmetic peptide raw materials to meet personalized brand and formulation needs. Our standardized OEM process is efficient, transparent and suitable for global cosmetic brands and manufacturers.
- Step 1: Demand Confirmation Communicate and confirm your customization requirements, including product purity, customized packaging, private label, special formula ratio and order quantity.
- Step 2: Scheme & Quotation We provide targeted customization solutions and official quotation according to your demands, and confirm the production cycle and service details.
- Step 3: Sample Confirmation Produce customized pre-samples for your testing and formula verification, adjust details until the sample meets your standards.
- Step 4: Mass Production Start formal mass production after sample confirmation. Strict quality inspection is implemented during the whole production process to ensure stable product quality.
- Step 5: Quality Inspection & Packaging Complete final testing, arrange customized packaging and private label printing, and provide complete qualification documents.
- Step 6: Delivery & After-sales Service Arrange global shipping on schedule, provide tracking information, and offer long-term technical after-sales support for customized products.
Frequently Asked Questions
Q1: What biological mechanism makes Palmitoyl Pentapeptide‑3 different from other cosmetic peptides?
A: It is a classic matrikine‑type signal peptide. Instead of paralyzing facial muscle fibers, it mimics native skin protein fragments to tell fibroblasts to generate more collagen, elastin and hyaluronic acid, rebuilding skin extracellular matrix from the dermal layer.
Q2: How long will consumers observe visible anti‑aging results in finished consumer skincare goods?
A: Visible improvements in skin smoothness and firmness generally appear after continuous use for 8‑12 weeks, subject to finished‑product concentration, skin condition and individual usage habitsAlibaba.co....
Q3: Can Palmitoyl Pentapeptide‑3 be mixed with retinol or vitamin‑A derivatives within one formulation?
A: Yes, synergistic anti‑aging effects can be achieved. Note that high‑strength retinol environments may accelerate peptide degradation. Formulators should control processing temperature and pH value, or separate them into dual‑phase packaging for maximum activity retention.
Q4: What risk factors may cause Matrixyl powder activity loss during storage?
A: Oxidation triggered by air exposure, high ambient temperature and ultraviolet irradiation will reduce peptide activity. Keep sealed, avoid direct sunlight, and avoid frequent repeated opening of original containers.
Q5: What is the difference between Palmitoyl Pentapeptide‑3 and Matrixyl 3000?
A: Palmitoyl Pentapeptide‑3 (Matrixyl) is a single‑component lipopeptide focusing on collagen stimulation. Matrixyl 3000 is a compound blend containing Palmitoyl Tripeptide‑1 plus Palmitoyl Tetrapeptide‑7, combining collagen‑boosting and anti‑inflammatory effects for complex anti‑aging targets.
Q6: Does this peptide raw material trigger skin irritation for sensitive‑skin end‑users?
A: Under recommended dosage range, Palmitoyl Pentapeptide‑3 delivers low‑irritation profiles. Finished product patch‑testing is still strongly suggested for final‑product validation before full‑scale launch.
Q7: What are the key points when dissolving Palmitoyl Pentapeptide‑3 powder in cosmetic formula preparation?
A: It shows limited pure‑water solubility. Pre‑dissolve in ethanol / propylene glycol aqueous mixture before adding into main formula phase. Operation temperature should not go above 45 ℃ to preserve biological activity.
Q8: What documentation can you provide to support EU market registration for cosmetic brands?
A: We supply CosIng matching statements, REACH‑relevant supporting documents, batch‑wise COA, SDS safety sheet and third‑party independent lab test reports, assisting your EU cosmetic‑product notification work.
delivery and shipping service
Storage: Store in a dry, cool, and well-ventilated place.
Packaging: 1 kg/bag, 25 kg/drum
Delivery Time: 7 days after order placement
1.Express Delivery
3-5 days for shipments under 100 kg
Door-to-door service
2.Ocean Freight
Over 300 kg: Approximately 30 days. Port-to-port service requires a professional customs clearance agent.
3.Air Freight
100kg-1000kg, 5-7 days
Airport-to-airport service, requires a professional customs clearance agent
Send inquiry or contact us to get free sample, and learn more details about it.
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