Products Description

Allantoin Powder High Purity Cosmetic Raw Material White Crystalline Powder

Allantoin is a synthetic/g plant-derived imidazolidine organic compound, chemically defined as 5-ureidohydantoin with a stable cyclic amide molecular structure. It features dual hydrophilic polar groups and a rigid cyclic skeleton, endowing it with unique physicochemical and physiological activity. Mechanically, it adheres to keratinocyte surfaces to form a breathable protective film, reducing transepidermal water loss and external irritant penetration. It accelerates epidermal cell proliferation and repairs damaged skin tissue by regulating fibroblast activity. Its molecular structure maintains chemical stability within pH 3.0–8.0 and tolerates conventional formulation heating below 80°C without decomposition or activity loss. Slightly soluble in cold water, solubility rises sharply with temperature; compatible with most cosmetic raw materials, non-volatile and non-phototoxic under daily storage and application conditions. It exhibits low sensitization and excellent biocompatibility, with natural biodegradability and no bioaccumulation.

Technical Specification

Item	Specification	Test Method
Purity Assay	≥99.0%	HPLC
Moisture Content	≤0.50%	GB/T 6283
pH (5% Aqueous Solution, 25°C)	4.5–6.0	GB/T 6368
Melting Point	226–240°C	GB/T 617
Heavy Metal (Pb)	≤10 ppm	ICP-MS
Arsenic (As)	≤2 ppm	ICP-MS
Residue on Ignition	≤0.10%	GB/T 7531
Microbial Count	≤10 CFU/g	GB 4789.2
Related Substances	≤0.05%	HPLC
Shelf Life	24 months	Sealed dry storage

Applications & Usage Restrictions

Main Applications (Recommended Dosage)

Sensitive Skin Skincare: Soothing lotion, repair cream (0.2–2.0%); relieve redness, inhibit mild inflammation, enhance skin barrier.
Facial & Body Cleansers: Amino acid cleanser, mild body wash (0.1–0.5%); neutralize surfactant irritation, reduce tightness after washing.
Baby Care Products: Baby lotion, bubble bath (0.1–0.3%); mild and non-irritating, prevent infant diaper rash and dry peeling.
Oral Care: Toothpaste, mouthwash (0.1–0.3%); soothe oral mucosa, relieve minor oral ulcer discomfort.
Post-Procedure Repair Products: Medical skincare gel, repair essence (1.0–2.0%); accelerate wound healing, reduce postoperative redness and sensitivity.
Hair Care: Anti-dandruff shampoo, conditioner (0.05–0.2%); soothe scalp inflammation, improve dry and itchy scalp.

Clear Restrictions

Not suitable for formulations with pH＜3.0 or pH＞8.0, easy to precipitate and lose activity.
Avoid high-concentration strong oxidant raw materials compounding, risk of molecular structural degradation.
Not recommended for industrial high-temperature strong alkali cleaning formulations; high temperature over 80°C for a long time will damage its efficacy.
Patients with urea metabolic disorders should avoid long-term contact with high-concentration allantoin formulations.

Safety Profile

Acute Toxicity: Rat oral LD50＞5000 mg/kg, dermal rabbit LD50＞5000 mg/kg, classified as non-toxic.
Skin Irritation: Rabbit skin irritation test score 0.3/4.0, human cumulative irritation test＜0.5/4.0, basically non-irritating.
Eye Irritation: In vitro EpiOcular model test shows no corneal damage; 2% concentration human eye test has no stinging and redness.
Genotoxicity: Ames test, in vitro chromosome aberration test and in vivo micronucleus test all negative, non-genotoxic.
Sensitization: Human patch test (120 patients) no allergic reaction, sensitization rate＜0.1%.
Phototoxicity: OECD 432 test negative, no phototoxic and photoallergic reaction.
Safety Certification: CIR approved for rinse-off and leave-on products with maximum addition 2.0%; compliant with FDA OTC skin protectant standard, EU Cosmetic Regulation 1223/2009; ISO 22716, GMP, SGS certified.

Allantoin Powder CAS 97-59-6 Skin Soothing Repair Raw Material

Why Choose Us

High Purity Stable Quality: Strictly implement USP/EP/JP pharmacopoeia standards, 99%+ high purity, batch-to-batch consistency, complete third-party test reports.
Strict Safety Compliance: Pass SGS, ISO 22716, GMP certification; full MSDS/TDS documents provided, meet FDA, EU and global cosmetic regulatory requirements.
Professional Technical Support: 8+ years of cosmetic raw material R&D experience, provide formula compatibility debugging, pH adaptation and stability testing technical guidance.
Adequate Supply Capacity: Monthly production capacity 800 MT, support 1kg sample packaging and 25kg drum bulk packaging, global fast delivery.
Eco-Friendly Raw Material: Adopt green synthetic process, low impurity residue, natural biodegradable, support clean beauty and natural cosmetic label claims.
Customized Service: Support customized particle size and microbial index according to customer formulation needs, one-stop raw material supply solution.

Full Stock

affordable price

Professional Team

advanced technology

Frequently Asked Questions

Is Allantoin Powder suitable for organic cosmetic formulations?

Yes, Allantoin complies with EU cosmetic regulations and ISO 22716 GMP standards, suitable for natural and organic cosmetic formula addition.

What is the recommended usage concentration of Allantoin in skincare products?

The conventional dosage is 0.2–2.0% for leave-on skincare products, 0.1–0.5% for cleansing products, and 1.0–2.0% for medical repair products.

Is Allantoin safe for sensitive skin and baby skin?

Absolutely. Allantoin is clinically proven non-irritating, non-sensitizing, with an extremely low allergic rate, ideal for sensitive skin, atopic skin and infant skincare.

What is the solubility of Allantoin Powder?

It is slightly soluble in cold water, easily soluble in hot water and glycerin, insoluble in ethanol, chloroform and ether; heating to 60–80°C can accelerate dissolution.

What is the stable pH range of Allantoin?

Allantoin remains chemically stable and active in pH 3.0–8.0 formulations; precipitation and inactivation will occur beyond this range.