Products Description
Derived from modern microbial fermentation and advanced lyophilization workflows, cosmetic‑grade Basic Fibroblast Growth Factor (bFGF, also known as FGF‑2, INCI name sh‑Polypeptide‑1) functions as a high‑value heparin‑binding recombinant polypeptide for premium skincare formulations. This animal‑free active raw material delivers consistent biological potency, ultra‑low endotoxin levels and high batch‑to‑batch uniformity for cosmetic manufacturing.
Acting as a vital cell‑signaling messenger, bFGF binds to specific receptors located on epidermal and dermal skin cells to modulate core skin metabolic routines. It supports skin resilience, encourages natural cell renewal and assists in restoring compromised skin barrier conditions. Our cosmetic‑standard bFGF raw material is strictly manufactured to meet global cosmetic regulatory benchmarks, ideal for formulating high‑end repair, anti‑aging and post‑aesthetic skincare ranges.
Technical Specification
| Item | Specification | Remarks |
|---|---|---|
| Common Name | Basic Fibroblast Growth Factor (bFGF / FGF-2) | Cosmetic raw material |
| CAS Number | 62031-54-3 | Global universal chemical registration number |
| INCI Name | sh-Polypeptide-1 | International cosmetic ingredient name |
| Molecular Formula | C₁₁₈H₁₇₃N₃₁O₃₃ | Molecular structural formula |
| Molecular Weight | ~17.3 kDa | Tested by electrophoresis |
| Appearance | White to off-white lyophilized powder | Visual inspection |
| Purity | ≥95% | Detected by SDS-PAGE electrophoresis |
| Biological Activity | ≥1.2×10⁷ IU/mg | Quantified cell activity detection |
| Endotoxin Content | ＜0.2 EU/µg | Limulus amebocyte lysate test |
| Shelf Life | 24 months (2 years) | Under specified storage conditions |
| Standard Packaging | 1 kg/bag, 25 kg/drum | Industrial & cosmetic bulk packaging |
| Recommended Dosage in Formulation | 0.001% - 0.01% | Cosmetic formula exclusive dosage range |
Safety Profile
Quantitative Safety Indicators
- Endotoxin: ＜0.2 EU/µg, meets EU & cosmetic grade endotoxin limit standards, no irritation risk for topical skin use.
- Microbial Limit: Total aerobic bacteria ＜10 CFU/g; Yeast & Mold ＜10 CFU/g; No pathogenic bacteria detected.
- Heavy Metal Residue: Lead ＜1 ppm, Arsenic ＜0.5 ppm, Mercury ＜0.1 ppm, Cadmium ＜0.1 ppm, compliant with global cosmetic heavy metal regulations.
- Skin Irritation Test: Acute dermal irritation test (rabbit model): Non-irritant; 28-day repeated dermal test: No cumulative irritation or allergic reaction observed.
- Eye Irritation Test: Mild irritation only in high-concentration direct contact; safe for normal facial cosmetic topical use after formula dilution.
- Comedogenicity: Non-comedogenic (Grade 0), will not block skin pores, suitable for oily and acne-prone skin.
- Systemic Toxicity: Topical application has extremely low skin transdermal absorption, no oral/inhalation toxicity risk; no genetic toxicity or teratogenicity detected in toxicological tests.
Attached Safety Certificates & Documents
We provide complete certification documents for each batch of products, which can be supplied with bulk orders:
- COA (Certificate of Analysis): Batch detection report including all technical parameters, purity, activity and endotoxin data.
- MSDS (Material Safety Data Sheet): Global unified safety data sheet, covering transportation, operation, storage and emergency handling guidelines, compliant with IATA, IMDG transportation regulations.
- Cosmetic Raw Material Registration Document: Included in the global cosmetic ingredient catalog, INCI: sh-Polypeptide-1, compliant with EU Cosmetic Regulation (EC) No. 1223/2009 and China Cosmetic Raw Material Directory.
- Stability Test Report: 24-month long-term stability test data under standard storage conditions, verifying activity retention rate ≥90%.
- Toxicological Safety Assessment Report: Dermal irritation, sensitization and microbial test reports for cosmetic applications.
Product Application
Our cosmetic‑grade bFGF powder fits leave‑on and rinse‑off skincare formulas, must be incorporated at processing temperature ≤40°C to preserve biological activity. Recommended dosage stays between 0.001%‑0.01% based on your target efficacy profile.
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Suitable Finished Cosmetic Categories
- Anti‑aging & skin firming items: facial serums, anti‑wrinkle essence, eye cream, firming face moisturizer
- Post‑procedure recovery skincare: beauty ampoules, repairing toner, recovery sheet masks for post‑microneedling / post‑laser home care
- Sensitive barrier‑damaged skincare: barrier repair cream, soothing essence, redness‑calming skincare solutions
- Daily revitalizing skincare: hydrating facial masks, revitalizing facial lotions, nourishing facial treatments
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Important Formulation & Usage Limitations
- Avoid co‑formulating with strong oxidizing agents, strong acid or strong alkali substances which will denature bFGF protein and eliminate bioactivity.
- Production temperature cannot exceed 40°C; add bFGF during the low‑temperature mixing phase.
- Finished goods need opaque packaging; long‑term direct UV exposure will degrade active performance.
- Intended solely for topical cosmetic skin applications. Forbidden for injection, oral consumption, food additives or pharmaceutical drug usage.
- Not designed for large exudative ulcer open wounds. People with known malignant skin lesions, pregnant or lactating individuals should seek dermatologist advice before using finished products containing this ingredient.
- Not compatible for hair dye, perfume or abrasive exfoliating cleaning product lines.
Why Choose our Company
- Rigorous batch‑wise quality management: Every lot undergoes full‑profile testing covering purity, bio‑activity, endotoxin and heavy metal content. Full COA documentation is available for bulk orders.
- Custom formulation technical support: Our cosmetic R&D team shares practical guidance on bFGF addition sequence, compatible excipient selection and stability optimization for your formula development.
- Complete compliance documentation kit: Supply MSDS, raw material registration files, toxicological assessment reports and stability test records to satisfy EU, China and other global cosmetic market entry requirements.
- Reliable inventory & flexible shipping alternatives: Stable stock of bFGF raw material, support sea freight, air freight and express delivery for small‑batch and bulk purchases.
- Mature biotech production craft: Adopt controlled microbial fermentation plus lyophilization process to secure stable activity and low impurity profile across production batches.
- Factory‑direct competitive pricing & customizable service: Flexible order volume, offer trial samples for your lab evaluation before formal bulk procurement.
OEM Service
We support diversified OEM & technical cooperation solutions for cosmetic brand clients, formulators and raw material distributors.
- Raw‑material OEM: Custom filling, special inner‑packaging for bFGF lyophilized powder, private label outer bag / drum marking according to your requirements.
- Formula consulting service: Provide reference formula suggestions, compatibility screening guidance, help you solve challenges about bFGF activity retention in finished skincare.
- Batch‑specific document customization: Adjust COA, specification sheet format to fit your local import & brand documentation requirements.
- Sample OEM: Supply lab‑scale custom sample packages for your R&D validation work.
- Joint development: Cooperate to develop stabilized bFGF derivative raw‑material solutions for complex cosmetic formula systems.
Frequently Asked Questions
Q1: What core skincare benefits can sh‑Polypeptide‑1 (bFGF) bring to topical cosmetic formulas?
A1: As a recombinant polypeptide signal factor, cosmetic‑grade bFGF helps regulate skin cell behaviors, supports barrier recovery, soothes irritated skin status, and works in anti‑aging formulations to improve skin texture and firmness appearance.
Q2: What is the optimal addition temperature for bFGF during cosmetic manufacturing?
A2: Always add bFGF when mixing temperature drops below 40°C. High temperature will denature protein structure and destroy biological activity. Adding at the final low‑speed mixing stage delivers best stability outcome.
Q3: Can bFGF be applied for oily and acne‑prone skin cosmetic formulas?
A3: Yes. This ingredient scores comedogenicity Grade 0, non‑pore‑clogging. It can be safely integrated into formulations targeting oily and blemish‑prone complexions when you follow the recommended dosage range.
Q4: What documents will you provide when placing bulk orders of bFGF raw powder?
A4: We supply Batch‑wise COA, MSDS safety sheet, cosmetic raw‑material registration supporting documents, toxicological safety evaluation summary and long‑term stability test reports.
Q5: Is free sample available for bFGF cosmetic raw material?
A5: We offer limited free evaluation samples for R&D purpose. You may submit sample inquiry, our sales team will confirm sample availability, shipping cost and lead time for you.
Q6: Which raw‑materials or chemical ingredients should avoid mixing together with bFGF?
A6: Do not combine with strong oxidants, concentrated strong acid and strong alkali. Those chemical environments will inactivate bFGF polypeptide protein completely.
Q7: How should finished cosmetic products containing bFGF be stored?
A7: Finished goods should be sealed, stored under cool and dry conditions away from sunshine / UV light. Opaque packaging is strongly suggested. The actual shelf‑life of finished cosmetics depends on your whole formula system.
Q8: Can bFGF raw material be used for making injectable or oral products?
A8: Absolutely not. Our bFGF is cosmetic‑grade raw material exclusively for external topical skincare. It is prohibited for injection, oral intake, food or medical drug production.
delivery and shipping service
Storage: Store in a dry, cool, and well-ventilated place.
Packaging: 1 kg/bag, 25 kg/drum
Delivery Time: 7 days after order placement
1.Express Delivery
3-5 days for shipments under 100 kg
Door-to-door service
2.Ocean Freight
Over 300 kg: Approximately 30 days. Port-to-port service requires a professional customs clearance agent.
3.Air Freight
100kg-1000kg, 5-7 days
Airport-to-airport service, requires a professional customs clearance agent
Send inquiry or contact us to get free sample, and learn more details about it.
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