Products Description
Basic Fibroblast Growth Factor (bFGF, also named FGF-2, INCI: sh-Polypeptide-1) is a recombinant heparin-binding polypeptide protein widely applied in cosmetic field. It is produced via microbial fermentation and lyophilization technology, featuring high purity, stable biological activity and low endotoxin. As a key cell signaling molecule, it acts on dermal and epidermal cells through specific receptor binding, participating in multiple skin physiological metabolic processes, and is a standardized active raw material for professional skin care formulations.
Technical Specification
| Item | Specification | Remarks |
|---|---|---|
| Common Name | Basic Fibroblast Growth Factor (bFGF / FGF-2) | Cosmetic raw material |
| CAS Number | 62031-54-3 | Global universal chemical registration number |
| INCI Name | sh-Polypeptide-1 | International cosmetic ingredient name |
| Molecular Formula | C₁₁₈H₁₇₃N₃₁O₃₃ | Molecular structural formula |
| Molecular Weight | ~17.3 kDa | Tested by electrophoresis |
| Appearance | White to off-white lyophilized powder | Visual inspection |
| Purity | ≥95% | Detected by SDS-PAGE electrophoresis |
| Biological Activity | ≥1.2×10⁷ IU/mg | Quantified cell activity detection |
| Endotoxin Content | ＜0.2 EU/µg | Limulus amebocyte lysate test |
| Shelf Life | 24 months (2 years) | Under specified storage conditions |
| Standard Packaging | 1 kg/bag, 25 kg/drum | Industrial & cosmetic bulk packaging |
| Recommended Dosage in Formulation | 0.001% - 0.01% | Cosmetic formula exclusive dosage range |
Safety Profile
Quantitative Safety Indicators
- Endotoxin: ＜0.2 EU/µg, meets EU & cosmetic grade endotoxin limit standards, no irritation risk for topical skin use.
- Microbial Limit: Total aerobic bacteria ＜10 CFU/g; Yeast & Mold ＜10 CFU/g; No pathogenic bacteria detected.
- Heavy Metal Residue: Lead ＜1 ppm, Arsenic ＜0.5 ppm, Mercury ＜0.1 ppm, Cadmium ＜0.1 ppm, compliant with global cosmetic heavy metal regulations.
- Skin Irritation Test: Acute dermal irritation test (rabbit model): Non-irritant; 28-day repeated dermal test: No cumulative irritation or allergic reaction observed.
- Eye Irritation Test: Mild irritation only in high-concentration direct contact; safe for normal facial cosmetic topical use after formula dilution.
- Comedogenicity: Non-comedogenic (Grade 0), will not block skin pores, suitable for oily and acne-prone skin.
- Systemic Toxicity: Topical application has extremely low skin transdermal absorption, no oral/inhalation toxicity risk; no genetic toxicity or teratogenicity detected in toxicological tests.
Attached Safety Certificates & Documents
We provide complete certification documents for each batch of products, which can be supplied with bulk orders:
- COA (Certificate of Analysis): Batch detection report including all technical parameters, purity, activity and endotoxin data.
- MSDS (Material Safety Data Sheet): Global unified safety data sheet, covering transportation, operation, storage and emergency handling guidelines, compliant with IATA, IMDG transportation regulations.
- Cosmetic Raw Material Registration Document: Included in the global cosmetic ingredient catalog, INCI: sh-Polypeptide-1, compliant with EU Cosmetic Regulation (EC) No. 1223/2009 and China Cosmetic Raw Material Directory.
- Stability Test Report: 24-month long-term stability test data under standard storage conditions, verifying activity retention rate ≥90%.
- Toxicological Safety Assessment Report: Dermal irritation, sensitization and microbial test reports for cosmetic applications.
Product Application
Applicable Cosmetic Products
Applied to leave-on & rinse-off skin care products with formula temperature control (processing temperature ≤40°C), recommended dosage: 0.001%–0.01%:
- Anti-aging & firming products: Facial serums, essences, anti-wrinkle creams, eye creams.
- Post-procedure repair products: Medical beauty after-care ampoules, repair lotions, recovery masks.
- Sensitive skin care products: Barrier repair creams, soothing essences, redness-relief skin care solutions.
- Daily skin care products: Hydrating masks, facial moisturizers, skin revitalizing lotions.
Clear Usage Restrictions & Forbidden Scenarios (Core Requirement: Restriction Explicit)
- Formula Restrictions
Forbidden to mix with strong oxidants, strong acids and strong alkalis, which will completely inactivate bFGF protein activity.
Processing temperature must not exceed 40°C; high-temperature heating (＞40°C) is prohibited during production.
Long-term direct exposure to strong ultraviolet light is forbidden; finished products need opaque packaging.
- Crowd Restrictions
Not recommended for users with confirmed malignant skin lesions or melanoma history (precautionary principle).
Pregnant women, lactating women and patients with severe skin diseases are advised to use under professional dermatologist guidance.
Not suitable for products used on damaged ulcerated skin with large-area exudation.
- Application Field Restrictions
Only for cosmetic topical skin care use; prohibited for oral products, injections, medical drugs and food additives.
Prohibited for hair dye, perfume and abrasive cleaning products.
- Storage & Use Restrictions for Finished Products
Finished products containing bFGF must be stored sealed, dry and cool; shelf life of finished products shall refer to the raw material activity retention period.
Why Choose our Company
- Strict Quantitative Quality Control System
- Professional R&D & Formula Technical Support
- Complete Certification & Cross-Border Trade Support
- Stable Inventory & Diversified Shipping Solutions
- Advanced Production Technology & Stable Product Performance
- Competitive Factory Direct Price & Flexible Service
Full Stock
affordable price
Professional Team
advanced technology
Frequently Asked Questions
Is bFGF suitable for sensitive skin formulations?
-
Yes. bFGF regulates inflammatory responses, repairs skin barrier, and soothes redness, itching, and irritation, making it safe for sensitive and barrier‑compromised skin.
What skincare products can bFGF be added to?
-
It is widely used in serums, essences, creams, masks, ampoules, and post‑repair products for anti‑aging, firming, and soothing applications.
What is the recommended usage rate in formulations?
-
Typical dosage is 0.001%–0.01%, adjusted based on formula type, target efficacy, and stability system. We provide free formulation guidance.
How to maintain bFGF activity during production?
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Avoid high temperatures (>40°C), strong oxidants, and prolonged light exposure. Add at low‑temperature mixing stage for better stability.
Can you provide free samples and COA?
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Yes. Free valid samples are available upon request. Full COA, MSDS, and stability data are provided with bulk orders.
delivery and shipping service
Storage: Store in a dry, cool, and well-ventilated place.
Packaging: 1 kg/bag, 25 kg/drum
Delivery Time: 7 days after order placement
1.Express Delivery
3-5 days for shipments under 100 kg
Door-to-door service
2.Ocean Freight
Over 300 kg: Approximately 30 days. Port-to-port service requires a professional customs clearance agent.
3.Air Freight
100kg-1000kg, 5-7 days
Airport-to-airport service, requires a professional customs clearance agent
Send inquiry or contact us to get free sample, and learn more details about it.
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