Products Description

D‑Glucosamine HCl is a naturally occurring amino sugar and a rate‑limiting precursor for the biosynthesis of glycosaminoglycans (GAGs), proteoglycans, and hyaluronic acid-key structural components of articular cartilage, synovial fluid, and connective tissues.

Mechanistically, it acts via three core pathways:

Anabolic stimulation: Enhances chondrocyte activity to upregulate synthesis of collagen II and aggrecan, supporting cartilage matrix formation and structural integrity.

Anti‑inflammatory modulation: Suppresses NF‑κB signaling and reduces production of pro‑inflammatory mediators (IL‑1β, TNF‑α, PGE2), lowering cartilage catabolism and joint inflammation.

Antioxidant & cytoprotective effects: Scavenges reactive oxygen species (ROS), reduces oxidative stress, and helps maintain cellular redox balance in joint tissues.

This product is manufactured via controlled hydrolysis of pharmaceutical‑grade chitin followed by low‑temperature spray drying to preserve molecular activity and solubility.

D-Glucosamine HCl powder white crystalline powder food grade pharmaceutical grade joint health ingredient

Technical Specification

Item	Standard
Appearance	White crystalline powder
Assay (Purity)	98.0–102.0%
Optical Rotation	+70° to +75° (c=1%, H₂O)
pH (1% aqueous solution)	3.0–5.0
Melting Point	190–194 °C
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Arsenic (As)	≤ 3 ppm
Heavy Metals (total)	≤ 10 ppm
Sulfate (SO₄²⁻)	≤ 0.24%
Yeast & Mold	≤ 100 CFU/g

Safety Profile

Toxicological Class: Low toxicity; EULAR assigns a low relative toxicity score for oral glucosamine formulations.
Common Adverse Events: Mild and transient, primarily gastrointestinal (nausea, bloating, soft stools); usually alleviated with food intake.
- Target Population Warnings:

Caution in individuals with shellfish allergy (raw material derived from crustacean exoskeletons).
Caution in patients on anticoagulant therapy (e.g., warfarin); potential increase in bleeding risk; INR monitoring recommended.
Not recommended in uncontrolled diabetes or severe hepatic impairment without professional supervision.

Pregnancy & Lactation: Insufficient safety data; use only under healthcare provider advice.
Regulatory Status: Complies with food‑grade and pharmaceutical‑grade purity requirements; not intended to diagnose, treat, cure, or prevent any disease.

Certifications (Safety & Quality)

ISO 9001 Quality Management System
FSSC 22000 Food Safety System
Non‑GMO Project Verified
Halal Certified
Kosher Certified
Full test reports: COA, MSDS, heavy metals, microbial, purity

Applications (Clearly Restricted)

Permitted uses limited to:

Oral dietary supplements: Tablets, capsules, powders, and softgels for joint health support (not for therapeutic claims).
Functional foods & beverages: Nutritional drinks, bars, and fortified food matrices (compliant with national food additive regulations).
Cosmetic ingredients: Skin‑care formulations for moisturizing and barrier support (INCI: Glucosamine HCl).
Veterinary health products: Companion‑animal joint supplements (formulation‑specific).

Restrictions: Not for injectable use; not for medical device coating; not for unapproved therapeutic claims.

FAQ

Q: Is D‑Glucosamine HCl suitable for vegetarians or vegans?

A: This product is derived from chitin (shellfish exoskeletons) and is not suitable for strict vegans or vegetarians. We offer non‑shellfish alternative upon request.

2.Q: What is the solubility of D‑Glucosamine HCl powder?

A: It is freely soluble in water, enabling clear, stable solutions for dietary supplements and functional beverages.

3.Q: Can this product be used in cosmetics?

A: Yes, it is compliant with cosmetic ingredient standards (INCI: Glucosamine HCl) and used for moisturizing and skin‑barrier support.

4.Q: How is your D‑Glucosamine HCl powder manufactured?

A: Produced via controlled hydrolysis of pharmaceutical‑grade chitin, followed by low‑temperature spray drying to ensure high purity and activity retention.