White crystalline D‑Glucuronolactone Powder, high purity ≥98%, CAS 32449‑92‑6

D‑Glucuronolactone is an endogenous cyclic ester metabolite derived from hepatic glucose oxidation. It acts as a critical co‑substrate in phase II hepatic glucuronidation, where it covalently conjugates lipophilic xenobiotics, drugs, and metabolic wastes to enhance water solubility and renal/biliary clearance. It supports extracellular matrix homeostasis by promoting collagen precursor synthesis, benefiting joint and connective tissue integrity. As a redox‑neutral energy‑supporting metabolite, it modulates cellular energy metabolism without stimulating catecholamine release, aiding physical fatigue recovery when combined with caffeine and taurine. It also reduces systemic inflammatory load by lowering toxin‑induced oxidative stress, supporting immune competence and skin barrier health.

Technical Specification (Quantitative)

Item	Standard	Test Method
Appearance	White crystalline powder	Visual inspection
Assay (HPLC)	≥98.0%	HPLC‑UV
Loss on Drying	≤1.0%	Gravimetry
Residue on Ignition	≤0.1%	Gravimetry
Heavy Metals (as Pb)	≤10 ppm	AAS/ICP‑MS
Arsenic (As)	≤2 ppm	AAS/ICP‑MS
Lead (Pb)	≤3 ppm	AAS/ICP‑MS
Mercury (Hg)	≤0.1 ppm	AAS/ICP‑MS
Melting Range	172–175 °C	Capillary method
Specific Optical Rotation	+18.0° to +20.0° (c=10, H₂O)	Polarimetry
pH (1% aqueous solution)	4.0–6.0	pH meter
Solubility	Freely soluble in water	Visual observation
Particle Size	95% through 80 mesh	Sieve analysis
Total Plate Count	≤1000 cfu/g	Aerobic plate count
Yeast & Mold	≤100 cfu/g	Plate count
Salmonella	Negative	Cultural method
E. coli	Negative	Cultural method

Safety Profile

Toxicological Class: Non‑toxic under intended use; WGK Germany 2
Acute Toxicity: LD₅₀ >5000 mg/kg (oral, rat); no acute toxicity at recommended doses
Chronic Exposure: No organ toxicity reported at dietary supplement levels
Side Effects: Mild transient headache or gastrointestinal upset may occur at >1000 mg/day
Hazard Statements: Non‑hazardous for transport; avoid eye/skin contact
Handling: Use dust mask; avoid inhalation; wash hands after handling
Storage: Dry, cool, sealed; avoid moisture & direct sunlight
Shelf Life: 24 months (unopened, proper storage)
Regulatory Status: Compliant with FCC, USP, EP; widely accepted as safe for food, supplement, and cosmetic use

Certifications

ISO 9001 | ISO 22000 | FSSC 22000 | HACCP
Halal | Kosher | GMP
COA | MSDS | Allergen Test Report | Microbial Test Report
Certificate images available for download in product resources.

Applications

Dietary Supplements: Oral tablets/capsules/powders; max 1000 mg/day per serving
Functional Beverages: Energy drinks, sports drinks; max 2.4 g/L; not for children/pregnant/lactating
Sports Nutrition: Pre‑/post‑workout formulas; within daily safe intake
Cosmetics & Personal Care: Skin care, lotions, serums; topical only; <5% formulation
Pharmaceutical Excipients: Adjuvant in detoxification preparations; for licensed drug formulation only
Prohibited Uses: Injectables, pediatric products without clinical approval, unapproved therapeutic claims

Delivery and Shipping Service

D‑Glucuronolactone Powder technical specification sheet with ISO Halal Kosher certificates

01.

Packaging and service

Storage: Store in a dry, cool, and well-ventilated place.

Packaging: 1 kg/bag, 25 kg/drum

Delivery Time: 7 days after order placement

02.

Delivery Methods

1.Express Delivery
3-5 days for shipments under 100 kg
Door-to-door service

2.Ocean Freight
Over 300 kg: Approximately 30 days. Port-to-port service requires a professional customs clearance agent.

3.Air Freight
100kg-1000kg, 5-7 days
Airport-to-airport service, requires a professional customs clearance agent

1kg bag and 25kg drum packaging of D‑Glucuronolactone Powder for wholesale export

FAQ

Q1: What is the mechanism of action of D‑Glucuronolactone in the body?

A: D‑Glucuronolactone acts as a glucuronyl donor in hepatic phase II metabolism, conjugating lipophilic toxins to form water‑soluble glucuronides excreted via urine/bile. It supports collagen synthesis for connective tissue health and modulates cellular energy metabolism to reduce fatigue.

Q2: Is D‑Glucuronolactone suitable for use in food and dietary supplements?

A: Yes. It is widely recognized as safe for functional foods, energy drinks, and dietary supplements, complying with FCC, USP, and major food safety standards.