Product Introduction

Light yellow‑brown fine powder of Ginkgo Biloba Leaf Extract, standardized 24% flavones 6% lactones

Ginkgo Biloba Extract is a standardized botanical extract derived from the dried leaves of Ginkgo biloba L. Its primary active constituents are flavonoid glycosides and terpene lactones (ginkgolides A, B, C, bilobalide).

Mechanisms of Action

Antioxidant Activity: Flavonoids scavenge reactive oxygen species (ROS), inhibit lipid peroxidation, and protect cell membranes from oxidative damage.

Microcirculation Improvement: Terpene lactones antagonize platelet‑activating factor (PAF), reduce platelet aggregation, enhance vascular endothelial function, and improve peripheral and cerebral blood flow.

Neurometabolic Support: Modulates neurotransmitter release and synaptic plasticity, supporting cognitive processing and memory consolidation under hypoxic or ischemic conditions.

Anti‑Inflammatory Modulation: Inhibits pro‑inflammatory mediators to alleviate chronic low‑grade inflammation associated with aging and circulatory stress.

This product is manufactured under strict quality control to ensure consistent levels of active markers, low ginkgolic acids, and compliance with international food and cosmetic safety standards.

Technical Specification

Item	Standard	Test Method

INCI Name	Ginkgo Biloba Leaf Extract	-
CAS No.	90045-36-6	-
Appearance	Light yellow‑brown fine powder	Visual
Total Flavonoid Glycosides	≥24.0%	HPLC
Total Terpene Lactones	≥6.0%	HPLC
Ginkgolic Acids	≤5 ppm	HPLC
Loss on Drying	≤5.0%	Gravimetry
Residue on Ignition	≤0.8%	Gravimetry
Heavy Metals (Total)	≤20 mg/kg	AAS/ICP‑MS
As (Arsenic)	≤2 mg/kg	AAS
Pb (Lead)	≤2 mg/kg	AAS
Cd (Cadmium)	≤0.5 mg/kg	AAS
Hg (Mercury)	≤0.1 mg/kg	AFS
Microbiological Total Plate Count	≤1000 cfu/g	Plate count
Yeast & Mold	≤100 cfu/g	Plate count
E. coli, Salmonella	Negative	Culture
Particle Size	95% pass 80 mesh	Sieve
Extraction Ratio	10:1 / 30:1 / 50:1 (customizable)	Calculation

Safety Profile

Acute Toxicity: LD50 >5000 mg/kg (oral, rat); practically non‑toxic under intended use levels.
Subchronic Toxicity: No organ toxicity observed at recommended dosages in 90‑day feeding studies.
Genotoxicity: Negative in Ames, chromosome aberration, and micronucleus tests.
Sensitization & Irritation: May be mild skin/eye irritant; dermal and respiratory sensitization potential exists in sensitive individuals.
Contraindications

Hypersensitivity to Ginkgo biloba or components.

Coagulation disorders, bleeding tendency, or preoperative patients (discontinue ≥36 hours before surgery).

Concomitant use with anticoagulants or antiplatelet drugs.

Pregnancy, lactation, infants, and toddlers.

Epilepsy or history of seizures (ginkgotoxin may lower seizure threshold).

Adverse Reactions: Rare and mild; may include headache, gastrointestinal upset, skin rash, or itching. Discontinue use if symptoms occur.
Special Populations: Elderly and diabetic patients require medical supervision; monitor blood glucose and bleeding risk.

Applications

Approved Uses Only

Dietary Supplements: For adults supporting cognitive function, peripheral circulation, and antioxidant status; not for children, pregnant/nursing women.
Cosmetic Formulations: Skin‑conditioning, antioxidant, and anti‑aging products (topical only; avoid mucous membrane contact).
Functional Foods & Beverages: As a natural antioxidant ingredient in compliance with national food additive regulations.
Animal Feed (Limited): For equine, canine, feline, and lagomorph feeds at specified safe inclusion levels; not for food‑producing livestock beyond authorized limits.

Prohibited Uses

Injectable or pharmaceutical drug formulations without regulatory authorization.
Use in foods for infants, children, or medical foods without approval.
Unregistered health claims for treating or curing diseases.

Certifications & Safety Documents

ISO 9001
Kosher
Halal
Non‑GMO Project Verified
Allergen‑Free
Non‑Irradiated
COA (Certificate of Analysis)
MSDS
Heavy Metals Statement
Microbial Test Report
GMP Compliance Certificate

Why Choose Us

Standardized Consistency: Strictly controlled ≥24% flavonoids and ≥6% terpene lactones; ginkgolic acids ≤5 ppm.
Sustainable Sourcing: Wild‑simulated cultivation in origin areas; traceable harvest and processing.
Advanced Production: GMP workshops, full‑chain quality control, and full‑set testing equipment.
Low Contaminant Profile: Heavy metals and microbes meet EU, US, and Japanese pharmacopoeia standards.
Flexible Customization: OEM/ODM for extraction ratios, particle size, solubility, and formulation support.
Global Logistics: Stable bulk supply; fast delivery via DHL, UPS, FedEx, EMS.
Full Documentation: Complete certificates, COA, MSDS, and regulatory support for customs and market entry.