Product Introduction

Huperzine A Powder 98% White Crystalline HPLC Tested

Huperzine A is a potent, reversible, selective acetylcholinesterase (AChE) inhibitor derived from Huperzia serrata. Its neuroactive effects are mediated by well‑defined molecular and cellular pathways:

Acetylcholinesterase InhibitionIt selectively and reversibly binds to the active site of AChE, blocking hydrolysis of acetylcholine (ACh) and elevating synaptic ACh levels to enhance cholinergic transmission, supporting learning, memory, and attention.
NMDA Receptor ModulationAs a mild, low‑affinity NMDA receptor antagonist, it reduces glutamate‑induced excitotoxicity and stabilizes neuronal membrane potential.
Antioxidant & Anti‑Apoptotic SignalingIt upregulates endogenous antioxidant enzymes, reduces ROS accumulation, inhibits caspase‑dependent apoptosis, and supports neuronal survival.
Neurotrophic SupportIt promotes expression of nerve growth factor (NGF) and related trophic factors, supporting synaptic plasticity and neuronal maintenance.
Blood–Brain Barrier PermeationIt efficiently crosses the blood–brain barrier to target central cholinergic pathways with minimal peripheral off‑target activity.

This product is manufactured via solvent extraction, chromatographic purification, and precise standardization for consistent purity and potency, intended for research, nutritional, and pharmaceutical formulation use.

Technical Specification

Item	Standard	Test Method
Huperzine A Assay	98.0% min (HPLC)	HPLC‑UV
Appearance	White to off‑white crystalline powder	Visual
Loss on Drying	≤3.0%	Gravimetry
Residue on Ignition	≤1.0%	Gravimetry
Heavy Metals (total)	≤10 mg/kg	AAS/ICP‑MS
Lead (Pb)	≤2.0 mg/kg	AAS
Arsenic (As)	≤1.0 mg/kg	AAS
Mercury (Hg)	≤0.1 mg/kg	AAS
Cadmium (Cd)	≤0.5 mg/kg	AAS
Pesticide Residues	Complies with USP/EP	GC‑MS
Total Aerobic Count	≤1000 cfu/g	Plate count
Yeast & Mold	≤100 cfu/g	Plate count
Escherichia coli	Negative	Culture method
Salmonella	Negative	Culture method
Particle Size	80–120 mesh	Sieve analysis

Safety Profile

Tolerability: Generally well‑tolerated at recommended doses; adverse effects are mild and cholinergic in nature.
Common Reactions: Nausea, diarrhea, vomiting, salivation, sweating, dizziness, muscle twitching, blurred vision; usually dose‑dependent and reversible.
Acute Toxicity: High safety margin; animal LD₅₀ >2000 mg/kg; no acute intoxication at therapeutic levels.
Special Populations:

Pregnancy & lactation: Not recommended; insufficient safety data.

Epilepsy/seizure disorders: Contraindicated or use only under strict medical supervision.

Cardiovascular conditions: Caution due to potential bradycardia or blood pressure changes.

Drug Interactions:

Concomitant use with other AChE inhibitors, cholinergics, or anticholinergics may cause additive effects.

May interact with anticoagulants, antiplatelets, or CNS‑active medications; consult a physician.

Contraindications: Hypersensitivity to Huperzia serrata or huperzine A; individuals with seizure disorders.
Handling: Avoid inhalation, eye/skin contact; use PPE in industrial settings.

Applications

For industrial formulation & research use only; NOT for direct human consumption as finished food, drug, or OTC product.

Dietary SupplementsCognitive health formulations (capsules, tablets, powders); restricted to adult oral supplements only.
Pharmaceutical R&DInvestigational neuroprotective formulations for mild‑to‑moderate cognitive impairment; limited to preclinical and clinical research.
Sports NutritionCognitive‑focus energy blends; restricted to adult oral use only.
Cosmetic & Topical FormulationsLimited to scalp/skin care for antioxidant and soothing claims; external use only.Prohibited Uses: Pediatric products, injectables, unapproved therapeutic drugs, clinical diagnosis/treatment.

Quality & Safety Certificates

Certificate of Analysis (CoA) per batch
HPLC Purity Report
Heavy Metals & Microbiological Test Report
MSDS (Safety Data Sheet)
ISO 9001, FSSC 22000, Halal, Kosher
Non‑GMO, Allergen‑Free, Non‑Irradiated Certificates

Why Choose Us

Precision StandardizationGuaranteed 1%, 5%, 98% huperzine A via HPLC; strict batch‑to‑batch consistency.
Ultra‑Purification TechnologyAdvanced chromatographic purification ensures high purity, low residues, and compliance with global standards.
Full Regulatory ComplianceComplete certifications and documentation for global markets (EU, US, Asia, Middle East).
Rigorous Quality ControlIn‑house lab testing for purity, potency, heavy metals, microbes, and pesticides; full traceability.
Flexible CustomizationTailored specifications, packaging, and private‑label solutions.
Reliable Supply ChainStable raw material base, short lead times, global logistics (express/air/sea), and on‑time delivery.