Products Description
Milk thistle extract is standardized to silymarin, a flavonolignan complex comprising silybin, silychristin, and silydianin. Its biological actions are driven by well‑defined molecular and cellular mechanisms:
- Hepatocellular Membrane StabilizationSilymarin integrates into the hepatocyte lipid bilayer, reinforcing structural integrity and reducing permeability to toxins, drugs, and ethanol metabolites.
- Antioxidant Defense via Nrf2 PathwaySilymarin activates the Nrf2‑ARE signaling cascade, upregulating phase II antioxidant enzymes (HO‑1, NQO1, GCL) and boosting intracellular glutathione levels to neutralize reactive oxygen species (ROS) and suppress lipid peroxidation.
- Anti‑Inflammatory ModulationIt inhibits NF‑κB translocation and reduces pro‑inflammatory cytokines (TNF‑α, IL‑1β, IL‑6), mitigating hepatic and systemic inflammation.
- Hepatocyte RegenerationSilymarin stimulates ribosomal RNA synthesis and protein translation, promoting repair and regeneration of damaged hepatocytes.
- Metabolic & Detoxification SupportIt modulates hepatic transporters (OATP1B1, NTCP, BSEP, MRP2) to enhance biliary excretion and clearance of endogenous and exogenous toxins.
This extract is manufactured via solvent extraction, concentration, and standardization to ensure consistent silymarin content, suitable for nutritional, functional food, and cosmetic formulations.
Technical Specification
| Item | Standard | Test Method |
|---|---|---|
| Silymarin Content | 80.0% min (UV) | UV‑spectrophotometry |
| Particle Size | 100% pass 80 mesh | Sieve analysis |
| Loss on Drying | ≤5.0% | Gravimetry |
| Ash Content | ≤5.0% | Gravimetry |
| Heavy Metals | ≤10.0 mg/kg | AAS/ICP‑MS |
| Lead (Pb) | ≤2.0 mg/kg | AAS |
| Arsenic (As) | ≤1.0 mg/kg | AAS |
| Mercury (Hg) | ≤0.1 mg/kg | AAS |
| Pesticide Residues | Negative | GC‑MS |
| Total Aerobic Plate Count | ≤1000 cfu/g | Plate count |
| Yeast & Mold | ≤100 cfu/g | Plate count |
| Escherichia coli | Negative | Culture method |
| Salmonella | Negative | Culture method |
Safety Profile
- General Tolerance: Silymarin is well‑tolerated in adults at recommended doses; adverse events are mild and comparable to placebo.
- Common Adverse Reactions: Mild gastrointestinal effects (bloating, nausea, loose stools) in sensitive individuals, likely related to increased bile flow.
- Allergy Warning: Contraindicated in persons with known allergy to Asteraceae/Compositae plants (ragweed, daisy, marigold, artichoke) due to potential cross‑sensitivity.
- Special Populations:
- Pregnancy & lactation: Use only under professional supervision due to limited clinical data.
- Hormone‑sensitive conditions: Caution advised for individuals with breast, uterine, or ovarian cancer, endometriosis, or uterine fibroids.
- Drug Interactions: May interact with cytochrome P450 2C9 substrates, anticoagulants (warfarin), antidiabetic agents, and immunosuppressants; consult a healthcare provider before concurrent use.
- Acute Toxicity: LD50 >5000 mg/kg in rodent models; no acute intoxication reported in humans at recommended intake levels.
Applications
This product is intended for industrial formulation only-not for direct human consumption as finished food or drug.
- Dietary SupplementsCapsules, tablets, softgels, powders for liver‑health support; restricted to oral supplement manufacturing.
- Functional Foods & BeveragesFortified drinks, bars, powders; limited to non‑medical functional food use.
- Cosmetic & Personal CareAntioxidant, soothing, and skin‑repair formulations (serums, creams, masks); restricted to topical external use only.
- Animal NutritionLiver support additives for pets and livestock; limited to animal feed manufacturing.Prohibited Uses: Not for injectable products, pediatric formulations without safety data, or unapproved therapeutic claims.
Quality & Safety Certificates
- Certificate of Analysis (CoA) per batch
- Heavy Metals & Microbiological Test Report
- Pesticide Residue Free Report
- ISO 9001, HACCP, Halal (available on request)
- SDS (Safety Data Sheet)
Why Choose Us
- Strict StandardizationConsistent silymarin content (40% / 80% / ratio extracts) verified by UV/HPLC, ensuring batch‑to‑batch reproducibility.
- 100% Natural & Clean LabelNo additives, fillers, artificial colors, or preservatives; non‑GMO, gluten‑free, allergen‑free.
- Full Quality ControlIn‑house lab testing for purity, potency, heavy metals, microbes, and pesticides; complete traceability from raw material to finished product.
- Customized SolutionsTailored specifications (ratio, solubility, particle size), packaging, and private‑label support.
- Reliable Supply ChainStable raw material base, short lead time (7 days), flexible logistics (sea/air/express), and professional documentation for customs clearance.
delivering and shipping service
Storage: Store in a dry, cool, and well-ventilated place.
Packaging: 1 kg/bag, 25 kg/drum
Delivery Time: 7 days after order placement
1.Express Delivery
3-5 days for shipments under 100 kg
Door-to-door service
2.Ocean Freight
Over 300 kg: Approximately 30 days. Port-to-port service requires a professional customs clearance agent.
3.Air Freight
100kg-1000kg, 5-7 days
Airport-to-airport service, requires a professional customs clearance agent
Frequently Asked Questions
Do you provide free samples for quality testing?
-
Yes, free samples are available for pre‑shipment verification; shipping cost may apply.
What is the shelf life and proper storage?
-
24 months in a cool, dry area, sealed and protected from direct light and high humidity.
Can this extract be used in cosmetics?
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Yes; it is widely used in topical skincare for antioxidant and soothing benefits, with INCI and CAS compliant for cosmetic labeling.
Is this milk thistle extract water‑soluble?
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We offer both standard and water‑soluble 80% silymarin grades to suit aqueous formulations.
What is the main active component in milk thistle extract?
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The primary active constituent is silymarin, a flavonolignan complex that exerts hepatoprotective, antioxidant, and anti‑inflammatory effects.
Send inquiry or contact us to get free sample, and learn more details about it.
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