Product Introduction

Natural Spermidine Powder Light Yellow to White Fine Powder HPLC Tested Wheat Germ Extract

Spermidine is an endogenous polyamine that regulates core cellular homeostasis. Mechanistically, it induces autophagy via multiple conserved pathways:

Inhibits acetyltransferase EP300, reducing protein acetylation and activating autophagy‑related genes (Atg5, Atg7, LC3, Atg12).

Modulates mTOR signaling and activates the ULK1/2‑Atg13‑FIP200 complex to initiate autophagosome formation.

Promotes hypusination of eIF5A, supporting autophagy flux and mitochondrial function.

Enhances FoxO3‑Atg signaling and HDAC4 nuclear translocation to sustain cytoprotective autophagy.

These actions clear damaged organelles and protein aggregates, reduce oxidative stress, stabilize nucleic acids, support membrane integrity, and maintain metabolic efficiency.

Product Specification

Item	Standard	Test Method
Appearance	Light yellow to white fine powder	Visual
Assay (Spermidine)	0.2%, 0.5%, 1.0%, 2.0%	HPLC
Extract Ratio	10:1, 20:1, 50:1	UV
Loss on Drying	≤12.0%	Gravimetry
Particle Size	100% through 80 mesh	Sieve
Heavy Metals	≤10 ppm	AAS
Arsenic (As)	≤1 ppm	AAS
Lead (Pb)	≤2 ppm	AAS
Cadmium (Cd)	≤0.5 ppm	AAS
Mercury (Hg)	≤0.1 ppm	AAS
Microbiological Total Plate Count	≤1000 cfu/g	USP
Yeast & Mold	≤100 cfu/g	USP
E. coli, Salmonella	Negative	USP
Shelf Life	24 months	Stability

Safety Profile

Toxicological Data

Oral LD₅₀ (mouse): >1000 mg/kg
90‑day repeated dose NOAEL (rat): up to 829 mg/kg bw/day
Non‑genotoxic in standard Ames and chromosome aberration assays
Human clinical doses up to 40 mg/day are safe and well‑tolerated

GHS & Handling

GHS Statement: H314 (causes severe skin burns and eye damage)
Precaution: P280 (protective gloves, clothing, eye/face protection); P305+P351+P338 (eye contact: rinse cautiously with water); P310 (immediately call a poison center/doctor)
UN Number: UN2735
Storage: Cool, dry, sealed, away from light and heat

Certifications

ISO9001, FSSC22000, Kosher, Halal, Non‑GMO, Allergen‑Free, Non‑Irradiated, Anti‑Doping compliant.

Applications

1. Nutraceuticals

Oral anti‑aging, metabolic, cardiovascular, and immune supplements

Max suggested use: ≤40 mg/day spermidine; not for parenteral use

2. Functional Foods & Beverages

Protein powders, energy drinks, nutrition bars, solid drinks

Max usage: ≤10 mg/serving; not for infant formulas

3. Cosmetics & Skincare

Anti‑aging serums, creams, masks; skin‑regeneration formulations

Topical only; avoid contact with eyes; not for injectable cosmetics

4. Pharmaceutical Support

Excipient/adjuvant for cell‑repair and metabolic support formulas

For R&D only; not as a sole active for disease treatment

Why Choose Us

Professional R&D TeamExperts in chemistry, biology, and nutrition; consistent process control and stable batch‑to‑batch quality.
Full International CertificationsISO9001, FSSC22000, Kosher, Halal, Non‑GMO, Allergen‑Free, Non‑Irradiated, Anti‑Doping.
Precision Quantification & TraceabilityHPLC/UV‑verified assay; full COA, MSDS, and heavy‑metal statements provided.
Mature Supply Chain50+ countries served; warehouses in US, Europe, Brazil, Mexico, SEA; fast delivery.
Flexible CustomizationCustom specifications (0.2%–2% spermidine; 10:1–50:1 extract ratio) and private labeling.