Products Description
Conotoxin peptides are disulfide‑rich, short‑chain neuroactive peptides isolated from the venom of marine Conus snails. This synthetic conotoxin peptide acts as a highly selective blocker of voltage‑gated ion channels, including N‑type calcium channels, sodium channels, and nicotinic acetylcholine receptors in the central and peripheral nervous systems.
By binding specifically to ion channel pore‑forming subunits, it inhibits calcium influx and blocks the release of nociceptive neurotransmitters (e.g., substance P, glutamate) in dorsal horn neurons, thereby suppressing pain signal transmission without activating opioid pathways. Its subtype selectivity enables precise modulation of neural excitability with minimal off‑target effects at therapeutic concentrations.
This product is manufactured via solid‑phase peptide synthesis (SPPS), purified by preparative HPLC, and lyophilized to ensure structural stability, batch‑to‑batch consistency, and suitability for research and formulation development.
Products Description
| Item | Standard Value | Test Method |
|---|---|---|
| Appearance | White to off‑white powder | Visual inspection |
| Purity (HPLC) | ≥90.0% | HPLC (C18 column, 220 nm) |
| Assay (Dry basis) | 90.0%–105.0% | HPLC external standard |
| Molecular Weight | Calculated ≈ 2600 Da | ESI‑MS |
| pH (1% solution) | 5.0–7.0 | pH meter |
| Loss on Drying | ≤5.0% | 105°C, 4 h |
| Residue on Ignition | ≤1.0% | 600°C, 4 h |
| Heavy Metals (Pb) | ≤10 ppm | AAS/ICP‑MS |
| As | ≤2 ppm | AAS/ICP‑MS |
| Total Aerobic Microbial Count | ≤100 cfu/g | USP <61> |
| Yeast & Mold | ≤10 cfu/g | USP <61> |
| Salmonella / E. coli | Negative | USP <62> |
| Storage Stability | ≥24 months at −20°C | Accelerated stability testing |
Safety Profile
- Acute Toxicity: Synthetic conotoxin peptides show high target selectivity; systemic toxicity is low at recommended research concentrations. Parenteral or high‑dose exposure may cause transient neurological effects.
- Irritation: Non‑irritating to skin and eyes under normal laboratory handling.
- Sensitization: No known sensitization in standard repeat‑exposure tests.
- Handling Risks: Avoid inhalation, direct skin contact, or mucous membrane exposure. Use PPE (gloves, goggles, lab coat).
- Storage: Store at −20°C, dry, sealed, protected from light to prevent degradation.
- Regulatory Note: For laboratory research, development, and formulation purposes only. Not for direct human or veterinary therapeutic use without further regulatory approval.
Applications
Neuroscience Research Tools.
Conotoxin Peptides serve as precise molecular probes to study the function and pharmacology of voltage-gated calcium, sodium, and potassium channels, as well as nicotinic acetylcholine receptors.
Pain Management and Analgesics.
Several conotoxin-derived compounds have been developed as potent analgesics. For example, Ziconotide, a synthetic conotoxin peptide, effectively blocks N-type calcium channels in the spinal cord, providing relief for severe chronic pain conditions with fewer side effects than conventional opioids.
Treatment of Neurological Disorders.
Due to their selective interaction with neural receptors and ion channels, conotoxins show promise in treating conditions like epilepsy, Parkinson's disease, and neuropathic pain.
Drug Development and Pharmacolog.
Conotoxins inspire design of new drugs targeting specific ion channels involved in cardiovascular, autoimmune, and neurodegenerative diseases.
Biotechnological Applications.
Conotoxin peptides are used to develop diagnostic tools and biosensors for detecting ion channel function and screening potential pharmaceuticals.
Safety & Quality Certifications
- ISO 9001 Quality Management System
- ISO 14001 Environmental Management
- GMP Facility for Peptide Manufacturing
- COA (Certificate of Analysis) per batch
- MSDS (16‑section safety data sheet)
- Third‑party test reports (HPLC, MS, microbial, heavy metals)
FAQ
Q:1.What is the purity and test method of your product?
A:Purity is ≥90% tested by HPLC; full COA is provided with every order.
Q:2.Is this product suitable for direct clinical or cosmetic use?
A:This product is for research and development only. It is not for direct therapeutic or unapproved cosmetic use.
Q:3.How should I store and transport Conotoxin Peptides?
A:Store at −20°C, dry, sealed, and protected from light. Transport with cold chain / dry ice to maintain stability.
Q:4.Can you customize purity, packaging, or labeling?
A:Yes, we support custom purity, bottle/bag/drum packaging, and private labeling for bulk orders.
delivering and shipping service
Storage: Store in a dry, cool, and well-ventilated place.
Packaging: 1 kg/bag, 25 kg/drum
Delivery Time: 7 days after order placement
1.Express Delivery
3-5 days for shipments under 100 kg
Door-to-door service
2.Ocean Freight
Over 300 kg: Approximately 30 days. Port-to-port service requires a professional customs clearance agent.
3.Air Freight
100kg-1000kg, 5-7 days
Airport-to-airport service, requires a professional customs clearance agent
Send inquiry or contact us to get free sample, and learn more details about it.
Hot Tags: Conotoxin Peptides, China Conotoxin Peptides manufacturers, suppliers, factory
