Products Description
Linaclotide Acetate is a synthetic 14-amino-acid tetradecapeptide, structurally homologous to endogenous guanylin and uroguanylin. It acts as a potent and selective Guanylate Cyclase-C (GC-C) agonist with local enteric pharmacological activity and minimal systemic absorption after oral administration.
Mechanically, Linaclotide and its active metabolite specifically bind to GC-C receptors on the luminal surface of intestinal epithelial cells. Receptor activation elevates intracellular and extracellular cyclic guanosine monophosphate (cGMP) levels. Intracellular cGMP activates the CFTR channel, promoting secretion of chloride and bicarbonate into the intestinal lumen, increasing intestinal fluid volume and accelerating gastrointestinal transit. Extracellular cGMP inhibits visceral pain nerve signaling, relieving abdominal discomfort and bloating. The compound retains targeted intestinal action with nearly undetectable blood concentration, avoiding widespread systemic pharmacological interference.
Applications
Linaclotide effectiveness
1.effective symptom relief: linaclotide works locally in the intestines to reduce pain and discomfort while promoting regular bowel movements.
2.dual action mechanism: it increases fluid secretion in the intestines and accelerates transit time, addressing both constipation and abdominal pain.
3.minimal systemic absorption: linaclotide acts primarily in the gut, ensuring targeted treatment with fewer systemic side effects.
4.clinically proven: extensive studies have demonstrated linaclotide's effectiveness in improving bowel habits and reducing abdominal pain in IBS-C and CIC patients.
Linaclotide uses and application areas
1.irritable bowel syndrome with constipation (IBS-C): reduces abdominal pain, bloating, and constipation.
2.chronic idiopathic constipation (CIC): promotes regular bowel movements in patients with persistent constipation of unknown cause.
Technical Specification
| Test Item | Specification Standard |
|---|---|
| Appearance | White to Off-white Amorphous Powder |
| Molecular Weight | 1526.8 ±1 Da |
| Purity (HPLC) | ≥98.0% |
| Total Related Impurities (HPLC) | ≤2.0% |
| Maximum Single Impurity (HPLC) | ≤1.0% |
| Moisture Content (Karl Fischer) | ≤8.0% |
| Acetonitrile Residue | ≤410 ppm |
| Acetate Content (HPLC) | 4.5%-5.5% |
| Host Cell Protein Residue | ≤0.01% |
| Host Cell DNA Residue | ≤10.0 ng/mg |
| Endotoxin | ＜1.0 EU/μg |
| Solubility | Slightly soluble in water, soluble in DMSO and methanol under slight heating |
Safety Profile
- Absorption Characteristics: Minimal systemic absorption after oral intake; undetectable in blood circulation within 3-5 hours, low systemic side effect risk.
- Adverse Reaction Profile: The most common mild adverse reaction is slight diarrhea (incidence ≤20%), usually occurring within 2 weeks of administration, dose-dependent and self-relieving. Occasional rare reactions include mild nausea and flatulence, no severe organ toxicity reported.
- Contraindications: Strictly prohibited for children under 2 years old; avoid use in 2-18 years old group due to dehydration risk. Not recommended for pregnant and lactating women without clinical safety data support.
- Toxicity Level: Classified as WGK 3 in Germany; oral acute toxicity Class 4, non-highly toxic raw material.
- Stability & Safety: Stable under sealed -20℃ storage; no degradation or harmful substance precipitation within 2-year shelf life.
Why Choose Us
- Strict Quality Control: All Linaclotide Acetate raw materials adopt full HPLC detection, strictly implement 98% minimum purity standard, each batch provides complete COA and spectrum data.
- Professional Customization: Support multiple packaging specifications (100mg/1g/100g/1kg) and customized impurity index requirements for medical and research institutions.
- Fast Global Delivery: Support DHL/UPS/FedEx air express, sea and air freight; arrange shipment within 24 hours after payment, global door-to-door delivery.
- Complete Certification Documents: Provide full set of safety detection certificates, third-party inspection reports, supporting customer customs clearance and product registration.
- Professional Technical Support: Professional peptide technical team provides mechanism consultation, parameter matching and after-sales technical guidance for pharmaceutical and research customers.
- Long-term Stable Supply: Large inventory of raw materials, stable production capacity, long-term exclusive supply agreement available for global pharmaceutical and biotech enterprises.
delivery and shipping service
Storage: Store in a dry, cool, and well-ventilated place.
Packaging: 1 kg/bag, 25 kg/drum
Delivery Time: 7 days after order placement
1.Express Delivery
3-5 days for shipments under 100 kg
Door-to-door service
2.Ocean Freight
Over 300 kg: Approximately 30 days. Port-to-port service requires a professional customs clearance agent.
3.Air Freight
100kg-1000kg, 5-7 days
Airport-to-airport service, requires a professional customs clearance agent
Frequently Asked Questions
What is the purity of your Linaclotide Acetate?
-
Our product purity is ≥98.0% tested by HPLC, total impurities controlled below 2.0%.
What is the main mechanism of Linaclotide Acetate?
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It activates intestinal GC-C receptors to elevate cGMP level, increase intestinal fluid secretion, accelerate gastrointestinal transit and relieve visceral abdominal pain.
Is Linaclotide Acetate easily absorbed into the blood?
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No, it has minimal systemic absorption, almost undetectable in blood, and only acts locally in the intestine.
What are the storage requirements for Linaclotide Acetate?
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Seal and store at -20℃, keep away from moisture, strong light and high temperature; shelf life is 2 years under sealed condition.
What are the application limitations of this product?
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It is only for pharmaceutical API synthesis and scientific research, prohibited for food, cosmetics, direct human use and children medication under 2 years old.
Send inquiry or contact us to get free sample, and learn more details about it.
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