Products Description
HATU is the most mainstream carbamate peptide coupling reagent in 2026 global peptide synthesis industry, irreplaceable auxiliary intermediate for GLP-1 weight-loss & hypoglycemic peptide drug production. It features high condensation efficiency, low amino acid racemization rate, mild reaction conditions, widely matched with Fmoc protected amino acid solid-phase synthesis process. As a matching supporting product of our self-produced Fmoc amino acids, HATU forms a complete GLP-1 synthesis raw material package, greatly increasing customer order unit price. Google search volume keeps rising year-on-year, main buyers are European peptide CDMOs, US biotech labs, Indian pharmaceutical peptide manufacturers.
Key Specifications Table
| Test Item | Specification |
|---|---|
| Chemical Name | O-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate |
| Appearance | White crystalline powder |
| HPLC Purity | ≥99.5% |
| Water Content | ≤0.08% |
| Insoluble Matter | ≤0.05% |
| Melting Point | 183~188℃ |
| Storage | Dry, sealed, low temperature, avoid moisture |
Application Field
- Condensation reagent for GLP-1 peptide synthesis (Semaglutide, Tirzepatide, Cagrilintide)
- Solid-phase peptide synthesis for all kinds of pharmaceutical active peptide fragments
- Custom polypeptide synthesis in university & pharmaceutical R&D laboratories
- Biotech CDMO mass peptide production auxiliary raw material
Dowell Product Advantages
- Matching supporting supply with our self-produced Fmoc protected amino acids, one-stop purchasing for peptide factories
- Ultra-high purity pharma grade, minimal side reaction impurities, reduces post-processing cost of peptide crude products
- Flexible order volume: gram-level lab samples to ton industrial bulk goods
- Stable inventory & fast delivery, regular stock for hot-selling peptide intermediates
- Complete analytical documents: COA, HPLC, NMR test reports to support customer filing
Packaging & Shipment
Storage: Store in a dry, cool, and well-ventilated place.
Packaging: 1 kg/bag, 25 kg/drum
Delivery Time: 7 days after order placement
1.Express Delivery
3-5 days for shipments under 100 kg
Door-to-door service
2.Ocean Freight
Over 300 kg: Approximately 30 days. Port-to-port service requires a professional customs clearance agent.
3.Air Freight
100kg-1000kg, 5-7 days
Airport-to-airport service, requires a professional customs clearance agent
Frequently Asked Questions
Q1: What is HATU (CAS 148893-10-1)? What are its key physical & chemical properties?
HATU (CAS 148893-10-1) is a high-purity coupling agent for organic and peptide synthesis. Key specs: Molecular Formula C₁₀H₁₅F₆N₆OP, MW 380.23, purity ≥98% HPLC. It is a white to pale yellow crystal powder, featuring stable properties and low racemization for chiral synthesis.
Q2: What are the main applications and advantages of HATU?
HATU is widely used in peptide synthesis, amide bond formation and pharmaceutical intermediate production. Compared with EDC and DCC, it delivers lower racemization, mild room-temperature reaction, fewer side reactions and higher yield, perfect for high-purity chiral compound synthesis.
Q3: What is the standard feeding procedure for HATU? What common mistakes should be avoided?
Standard process: Dissolve carboxylic acid and base (DIPEA/NMM) in anhydrous DCM/DMF/DMSO, add HATU for 3-5 mins activation, then add amine. Avoid direct HATU-amine mixing, excessive base and high temperature, which cause impurities and racemization.
Q4: What are HATU by-products and how to purify products efficiently?
HATU main by-products are HOAt and tetramethyluronium hexafluorophosphate. Efficient purification includes acid-base water washing, column chromatography and resin cleaning to remove residual impurities and guarantee high product purity.
Q5: What are the storage conditions, shelf life and safety precautions of HATU?
HATU is moisture-sensitive. Store sealed, light-proof at 2-8℃ with 2-year shelf life in dry environment. Moisture and heat cause decomposition. Wear protective gear during use, keep away from strong oxidants and corrosives, and use only anhydrous solvents for reactions.
Q6: What is the difference between HATU, COMU and TBTU? How to select the right reagent?
HATU, TBTU and COMU are common coupling reagents. TBTU suits non-chiral synthesis only. HATU offers low racemization and high cost performance for chiral peptide & pharmaceutical synthesis. COMU is low-toxic and high-solubility but costly. Select HATU for standard chiral synthesis, COMU for green processes, TBTU for simple non-chiral reactions.
Fixed Disclaimer
Disclaimer: All pharmaceutical intermediates provided by Dowell Ingredients are exclusively for laboratory research and pharmaceutical synthetic R&D use. Finished controlled APIs are not available for direct sales. Formal enterprise qualification review is required prior to quotation and bulk order arrangement.
Send inquiry or contact us to get free sample, and learn more details about it.
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