Name: China γ-Polyglutamic Acid (γ-PGA) Cosmetic Grade Manufacturers Suppliers Factory - Customized Service - Dowell Healthy
Brand: Dowell
SKU: 296349848

Products Description

Cosmetic Grade γ-Polyglutamic Acid γ-PGA White Powder INCI Polyglutamic Acid CAS25513-46-6 Raw Material Sample

γ-Polyglutamic acid (γ-PGA) is a linear biodegradable homo-polymer biosynthesized via submerged aerobic fermentation of Bacillus subtilis, with glutamic acid monomers linked by gamma-peptide bonds to construct long hydrophilic macromolecular chains abundant in free side-chain carboxyl (-COOH) and terminal carboxyl groups.

Technical Specification

Test Item	Quantified Specification Standard	Test Detection Method
INCI / CAS	INCI: POLYGLUTAMIC ACID; CAS:25513-46-6	Global CosIng database registration
Appearance	Uniform white fine free-flowing powder, no visible agglomeration	Visual inspection under natural light
γ-PGA Purity (Dry Basis)	≥92.0 wt%	HPLC high-performance liquid chromatography
Loss on Drying	≤8.0 %	Drying oven at 105℃, constant weight method
pH Value (1% aqueous solution, 25℃)	6.3 ~7.3	Digital pH meter testing
Molecular Weight (Cosmetic Grade Standard)	High MW:700~1200 KDa; Medium MW:70~150 KDa	Gel Permeation Chromatography(GPC)
Viscosity (1% solution,60rpm,25℃)	≥90 mPa·s	Rotational viscometer
Heavy Metal Limit	Pb ≤10 ppm; As ≤2 ppm; Hg ≤0.1 ppm; Cd ≤1 ppm	ICP-MS elemental analysis
Microbiological Index	Total Aerobic Count ≤100 CFU/g; Yeast & Mold ≤10 CFU/g; Salmonella/E.Coli/Staph absent	ISO 16212 microbial test
Solubility	100% fully soluble in deionized water at 25℃, no insoluble residue	Water solubility experiment
Shelf Life	24 months under sealed cool & dry storage	Accelerated stability test

Safety Profile

Quantitative Safety Test Data

Acute Toxicity: Oral LD₅₀＞5000mg/kg (rat), classified as practically non-toxic via OECD 423 guideline test; no acute percutaneous toxicity observed in 2000mg/kg dermal test (OECD402).
Irritation Test: Human closed patch test (n=120 volunteers, 48h occlusion): zero erythema/edema response, skin irritation index =0; Ocular irritation test: non-irritant per OECD405 standard.
Sensitization Test: Guinea pig maximization test(GPMT): skin sensitization rate＜0.1%, non-allergenic raw material; no phototoxicity & photoallergy under UV exposure test.
Genotoxicity: Ames test & chromosome aberration test: negative result, no mutagenic potential per OECD471/473.

Available Official Safety Certificates

COA (Certificate of Analysis): Batch-wise full test report matching above technical specs, issued by third-party cosmetic testing lab;
MSDS (Material Safety Data Sheet): GHS-standard global version compliant with EU REACH & US OSHA regulation;
CIR Safety Review Document: Compliant with US Cosmetic Ingredient Review safety specification;
Non-heavy metal test report from CNAS accredited laboratory;
Food-contact & cosmetic raw material qualification certificate (China NMPA cosmetic raw list included, No.03881).

Applications

Facial Essence & Ampoule Serum: Recommended addition:0.5~1.0% only; restricted to leave-on facial skincare, forbidden for rinse-off cleanser base material;
Facial Lotion & Moisturizing Cream: Recommended addition:0.1~0.5%; not allowed to replace emulsifier entirely, auxiliary moisturizer only;
Disposable Sheet Mask/Eye Mask/Sleeping Mask: 0.2~0.8% addition limit; only for water-phase formulation component;
Barrier Repair Sensitive Skin Skincare: 0.1~0.4% fixed dosage; no combination with high-concentration acid ingredients＞5%;
Facial Sunscreen & Color Cosmetics (BB/Foundation): Max addition ≤0.3%; used for improving spreadability & hydration only, not as primary UV filter;

❌ Forbidden Application Scenarios

Not allowed for oral cosmetic, lip care edible-grade raw material;
Prohibited for injection-grade medical raw material;
Not applicable for high-concentration peeling skincare with pH＜3.0 formula

Frequently Asked Questions

Is γ‑Polyglutamic Acid suitable for sensitive skin?

Yes. Our γ-PGA is biodegradable, non-irritating, and free of harmful substances. It is compatible with most skin types, including sensitive and fragile skin, and will not cause redness, itching, or other discomfort.

What is the recommended usage rate in cosmetics?

The typical dosage of γ-PGA in final cosmetic formulations is 0.05% – 1.0%. You can adjust the dosage according to the product type (e.g., essence: 0.5-1.0%, lotion: 0.1-0.5%) and desired moisturizing effect.

How should I store this product?

Please store γ-PGA in a dry, cool, well-ventilated area away from direct sunlight and high humidity. Keep the package sealed when not in use to prevent moisture absorption and ensure product stability.

What is the shelf life of Dowell γ‑Polyglutamic Acid?

Under proper storage conditions (dry, cool, sealed), the shelf life of our γ-PGA is 24 months. Please use the product within the shelf life for the best efficacy.

Do you provide samples and technical documents?

Yes. We offer free test samples (5-10g) for your evaluation. We also provide complete technical documents, including COA (Certificate of Analysis), MSDS (Material Safety Data Sheet), formulation guides, and application data to support your product development.