Products Description

Cosmetic Grade Pure Glutathione Powder White Crystalline Powder CAS 70-18-8

Glutathione (GSH) is a endogenous γ-L-glutamyl-L-cysteinylglycine tripeptide composed of glutamic acid, cysteine, and glycine, widely distributed in mammalian cells.

Core Mechanisms

Redox Homeostasis & AntioxidationGSH acts as a cellular reductant that directly neutralizes reactive oxygen species (ROS) and free radicals via thiol-disulfide exchange. It supports the glutathione peroxidase cycle and regenerates vitamins C/E, stabilizing the intracellular antioxidant network.

Melanin ModulationGSH inhibits tyrosinase activity and shifts melanin synthesis from eumelanin to pheomelanin, reducing hyperpigmentation, dark spots, and UV-induced discoloration without cytotoxicity.

Detoxification PathwayVia glutathione S-transferase (GST) catalysis, GSH forms conjugates with electrophilic toxins, heavy metals, and xenobiotics, enhancing hepatic and cutaneous clearance.

Skin Barrier & Matrix SupportGSH preserves keratinocyte viability, reduces oxidative degradation of collagen/elastin, and improves skin density and elasticity by lowering inflammatory cytokines.

Technical Specification

Item	Standard Value	Test Method
Assay (Glutathione)	≥99.0%	HPLC
Appearance	White crystalline powder	Visual
Loss on Drying	≤1.0%	Gravimetry
Residue on Ignition	≤0.1%	Gravimetry
Heavy Metals (Pb)	≤10 ppm	AAS
Arsenic (As)	≤2 ppm	AAS
Melting Point	182–195 °C	Capillary
Solubility	~50 mg/mL in water	Dissolution test
pH (1% aqueous solution)	5.5–7.0	pH meter
Particle Size (D90)	≤150 μm	Laser diffraction
Microbial Total Plate Count	≤100 cfu/g	USP <61>
Yeast & Mold	≤10 cfu/g	USP <61>
Salmonella / E. coli	Absent	USP <62>

Safety Profile

CIR Safety Assessment: Safe for topical cosmetic use at concentrations up to 2%
Acute Toxicity: LD₅₀ >5000 mg/kg (oral, rat); non-toxic under normal handling
Skin Compatibility: Non-irritating in patch tests; rare mild transient erythema at >3%
Eye Hazard: May cause mild irritation; avoid direct contact
Sensitization: No confirmed skin sensitization in human repeat-insult patch test
Stability: Sensitive to oxidation, heat, and light; store in dry, cool, airtight conditions
Restrictions

Not for intravenous, intramuscular, or subcutaneous injection

Not for oral pharmaceutical or food use

Not for unlicensed skin-whitening injections

For external cosmetic manufacturing only

Applications

Permitted Cosmetic Applications

Brightening Serums: 1–3% for uneven tone, post-inflammatory hyperpigmentation
Anti-Aging Creams/Lotions: 1–2% to reduce oxidative aging and fine lines
Hydrating Masks: 1–2% for revitalizing dull, stressed skin
Skin-Brightening Soaps: 0.5–1% for gentle daily brightening cleansing
Dermatological Topical Formulations: Professional leave-on products under cosmetic guidelines

Strictly Prohibited Uses

Injectable products (IV/IM/SC)
Oral supplements, foods, beverages, or pharmaceuticals
Implantable or medical devices
Products for internal or systemic administration

Safety & Quality Certifications

ISO 9001 Quality Management System
ISO 22716 Cosmetic GMP
MSDS (16-section compliant)
COA with full QC data
Heavy metals & microbiology test reports
Stability test summary

Why Choose Us

Stable ≥99% HPLC Purity: Consistent batch-to-batch performance
Low Microbial & Heavy Metals: Meets EU and US cosmetic raw material limits
Controlled Particle Size: Improves solubility, dispersion, and formulation stability
Cold & Dry Processing: Preserves reduced GSH activity, minimizes oxidation
Flexible Packaging: 1 kg foil bag / 25 kg fiber drum; customizable options
Fast Lead Time: 7 working days after order confirmation
Global Logistics: Express (3–5 days), air (5–7 days), sea (≈30 days); door-to-door support
Full Documentation: COA, MSDS, specs, certificates, and formulation guidance