Product Introduction
Artemisinin is a naturally occurring sesquiterpene lactone bearing an essential endoperoxide bridge as its pharmacophore. Upon entering parasitized erythrocytes, the endoperoxide moiety undergoes reductive cleavage mediated by ferrous iron (Fe²⁺) derived from hemoglobin digestion, generating carbon‑centered free radicals and reactive oxygen species (ROS). These reactive intermediates alkylate and damage critical parasitic proteins, lipids, and nucleic acids, disrupting membrane integrity, mitochondrial function, and cellular homeostasis, leading to rapid parasite death.
Beyond antimalarial activity, artemisinin modulates inflammatory signaling pathways and reduces oxidative stress by scavenging free radicals and supporting cellular redox balance. Its low systemic toxicity at therapeutic levels and broad‑spectrum antiparasitic potential support its use in targeted anti‑infective, immunomodulatory, and antioxidant formulations.
Product Specification
| Parameter | Value | Test Method |
|---|---|---|
| Appearance | White to off‑white crystalline powder | Visual |
| Purity (Artemisinin) | ≥99.0% | HPLC |
| Melting Point | 156–157 °C | Thermal analysis |
| Boiling Point | 389.9 °C (760 mmHg) | Calculated |
| Density | 1.24 g/cm³ | Pycnometer |
| Flash Point | 172 °C | Closed cup |
| Loss on Drying | ≤1.0% | Gravimetry |
| Residue on Ignition | ≤0.1% | Gravimetry |
| Heavy Metals (Pb, As, Hg, Cd) | Pb ≤10 ppm; As ≤2 ppm; Hg ≤1 ppm; Cd ≤1 ppm | ICP‑MS |
| Microbial Limits | Total plate count ≤1000 cfu/g; Yeast/Mold ≤100 cfu/g; E. coli, Salmonella: Absent | USP |
| Solubility | Soluble in chloroform, acetone, diethyl ether, ethyl acetate; practically insoluble in water | Visual solubility |
| Storage Condition | 2–8 °C, sealed, dry, light‑protected | - |
| Shelf Life | 24 months (unopened, proper storage) | Stability study |
Safety Profile
- General Toxicity: Favorable safety profile at recommended use levels; acute and subchronic toxicity low in preclinical models.
- Adverse Reactions: Mild, transient effects may include gastrointestinal upset, headache, dizziness; rare hypersensitivity reactions.
- Contraindications: Contraindicated in individuals with known hypersensitivity to artemisinin or Artemisia‑derived ingredients.
- Pregnancy & Lactation: Not recommended in first trimester; use in second/third trimesters and lactation only under qualified professional supervision.
- Neurological & Cardiac: No clinically significant neurotoxicity or cardiotoxicity reported at intended formulation levels; high‑dose animal data not directly extrapolatable to human use.
- Hepatic & Renal: Mild, reversible liver enzyme elevations reported rarely; use cautiously in severe hepatic or renal impairment.
- WHO Guidance: Artemisinin monotherapy for malaria is not recommended to reduce resistance risk; intended for R&D and formulated end‑use only.
Applications
- Pharmaceutical R&D: Intermediate for artemisinin‑based combination antimalarial therapies (ACTs), non‑clinical in vitro/in vivo research.
- Nutraceuticals: Dietary supplements with anti‑inflammatory, antioxidant, immune support claims (compliant with local food supplement regulations).
- Cosmetic Ingredients: Topical antioxidant, soothing formulations for skin care (not for injectable or ophthalmic use).
- Biological Research: In vitro tool for antiparasitic, anti‑inflammatory, and redox biology studies.
Strictly Prohibited Uses
- Standalone antimalarial treatment for human or veterinary use (per WHO guidelines).
-
Injectable, intravenous, intraocular, or mucosal drug products without full clinical approval.
-
Food additives for general daily foods (reserved for regulated supplements).
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Use in products intended to diagnose, cure, mitigate, treat, or prevent disease in humans without regulatory marketing authorization.
Certifications & Compliance Documents
- EU Organic / NOP Organic
- ISO 9001
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Kosher / Halal
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COA (Certificate of Analysis)
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MSDS
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Allergen‑Free Statement
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GMO‑Free Certificate
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Non‑Irradiated Statement
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Anti‑Doping Compliance
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Food Grade Certificate
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Heavy Metals Test Report
Packaging & Shipping
Packaging and service
Storage: Store in a dry, cool, and well-ventilated place.
Packaging: 1 kg/bag, 25 kg/drum
Delivery Time: 7 days after order placement
Delivery Methods
1.Express Delivery
3-5 days for shipments under 100 kg
Door-to-door service
2.Ocean Freight
Over 300 kg: Approximately 30 days. Port-to-port service requires a professional customs clearance agent.
3.Air Freight
100kg-1000kg, 5-7 days
Airport-to-airport service, requires a professional customs clearance agent
FAQ
Q: Is your Organic Artemisinin 99% suitable for use in cosmetic formulations?
A: Yes, it can be used in topical cosmetic formulations as an antioxidant and soothing agent, provided you comply with your country's cosmetic ingredient regulations. It is not for injectable or ophthalmic preparations.
Q: Do you provide a valid COA and full safety data sheet (MSDS)?
A: Yes, we supply a detailed Certificate of Analysis (COA) and up‑to‑date MSDS with every order. Additional safety and compliance documents are available on request.
Q: What is the maximum recommended shelf life and proper storage?
A: The shelf life is 24 months when stored unopened at 2–8 °C in a dry, light‑protected environment. Avoid moisture, heat, and direct sunlight during transport and storage.
Q: Can this product be used as a standalone antimalarial drug?
A: No. This material is a raw ingredient for R&D and formulated products only. WHO guidelines prohibit artemisinin monotherapy for malaria treatment to prevent resistance development.
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