Brief Introduction
Nobiletin is a rare and high-value polymethoxylated flavone exclusively sourced from ripe citrus peels, including mandarin, tangerine and sweet orange. Classified as -Hexamethoxyflavone, it features six methoxy functional groups on its flavone skeleton - a unique structural trait that distinguishes it from common citrus flavonoids. This special molecular structure grants Nobiletin exceptional lipophilic activity and superior tissue permeability, enabling it to exert bioactive effects more efficiently than ordinary antioxidant ingredients.
Our factory adopts low-temperature physical extraction and high-precision chromatographic purification technology to produce high-purity Nobiletin. The entire production process avoids harmful chemical residues, ensuring batch consistency, ultra-low heavy metal content and stable physical and chemical properties. It serves as a premium raw material for high-end cosmetic formulation, functional nutritional product development and biomedical experimental research.
Unique Bioactive Functions & Scientific Benefits
Modern phytological and pharmacological studies have verified the diverse functional advantages of Nobiletin, making it a trending ingredient in health and beauty industries:
- Powerful free radical neutralizing capability, effectively reducing oxidative stress in human cells
- Regulates endogenous inflammatory mediators, assisting in soothing mild skin irritation and bodily inflammatory responses
- Modulates lipid metabolism pathways, contributing to healthy body fat and lipid level maintenance
- Possesses remarkable anti-photoaging properties, protecting skin cells from UV-induced oxidative damage and aging signs
- Exerts potential neuroprotective and cardiovascular protective effects in preclinical experimental models
- Creates prominent synergistic effects when compounded with other citrus flavonoids like Tangeretin and Sinensetin for enhanced overall efficacy
Professional Application Scenarios
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High-End Cosmetic Active Ingredients
Nobiletin is widely added into anti-aging, photo-repair and antioxidant skincare products. It effectively relieves skin damage caused by ultraviolet radiation and environmental pollution, improves skin dullness, and maintains stable and healthy skin barrier condition.
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Functional Nutraceutical Raw Materials
As a natural plant-derived antioxidant, it is applied in the research and development of metabolic care and antioxidant dietary supplements, providing mild and safe nutritional support for human body regulation.
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Biomedical & Laboratory Scientific Research
It acts as a standard reference substance and core experimental reagent for flavonoid mechanism research, cell culture experiments and in-vitro pharmacological testing in global laboratories.
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Compound Plant Extract Formulation
Professional compound formula customization is available by blending Nobiletin with multiple citrus polymethoxyflavones to achieve multi-dimensional bioactive effects.
Specifications
- Purity: ≥98% HPLC / ≥99% HPLC (customizable)
- Loss on Drying: ≤0.5%
- Heavy Metals: Pb＜10ppm, As＜2ppm, Cd＜1ppm, Hg＜1ppm
- Residual Solvents: Compliant with ICH Q3C guidelines
- Microbial Limit: Total aerobic bacteria ＜1000 CFU/g; Yeast & Mold ＜100 CFU/g
- Storage: Hermetically sealed, cool dry place, avoid light; long-term storage recommended at -20℃
- Shelf Life: 24 months under proper storage conditions
Packaging & Shipment
- Lab sample: 10g, 100g aluminum foil vacuum bag
- Industrial bulk: 25kg fiber drum with double PE inner bag
- Sea FOB shipping for large batch orders, air express for small trial samples
1.Express Delivery
3-5 days for shipments under 100 kg
Door-to-door service
2.Ocean Freight
Over 300 kg: Approximately 30 days. Port-to-port service requires a professional customs clearance agent.
3.Air Freight
100kg-1000kg, 5-7 days
Airport-to-airport service, requires a professional customs clearance agent
OEM & Customized Processing Service
We offer one-stop personalized customization services for Nobiletin to match different industrial formulation and research thresholds, covering full-link customized solutions:
- Customized purity modification: Adjustable 98%-99.9% high-precision purity standards
- Custom compound blending: Professional proportional compounding with Tangeretin, Sinensetin and other citrus flavonoids
- Custom packaging and labeling: Exclusive private label design, customized outer packaging and batch marking
- Customized testing items: Additional detection of pesticide residues, microbial limits and heavy metal indicators as required
- Customized technical documents: Tailored COA, SDS and technical manuals that meet local import standards of various countries
All customized projects support pre-production sample confirmation to ensure zero deviation from customer requirements. Contact our sales team to get a exclusive customized quotation.
Why Choose Xi'an Dowell Healthy Nobiletin?
- Stable Global Supply Chain: Self-owned production base and permanent spot inventory ensure uninterrupted supply of high-purity Nobiletin, covering small sample orders and large-tonnage bulk orders
- Strict Full-Process QC System: Every production batch undergoes independent HPLC testing and multi-index inspection, with traceable raw material sources and complete quality archives
- Professional R&D Technical Team: Provide one-on-one technical guidance on ingredient solubility, formula compatibility, application methods and storage precautions
- Factory Direct Sales Advantage: Direct sales mode eliminates middlemen profit difference, offering transparent and cost-effective pricing for global partners
- Complete Export Qualifications: Rich export experience and complete certification system to smoothly support customs clearance in various countries
- Multi-Mode Logistics Guarantee: Equipped with professional moisture-proof and light-proof packaging, supporting flexible logistics solutions of express, air and sea transportation
- Strict Business Confidentiality Mechanism: Sign confidential agreements for all customized projects to fully protect customers' formula data and commercial privacy
Frequently Asked Questions
Q1: What are the main applications of Nobiletin?
A1: Nobiletin is a natural polymethoxyflavone extracted from citrus peels. It is widely used as raw material for anti-aging cosmetics, nutraceutical formula development and pharmacological cell research due to antioxidant and anti-inflammatory properties.
Q2: What is the CAS number of Nobiletin?
A2: The CAS number of Nobiletin is 478-01-3, chemical name 5,6,7,8,3',4'-Hexamethoxyflavone.
Q3: How is the solubility of Nobiletin powder?
A3: Nobiletin dissolves well in ethanol, methanol and DMSO. It has low solubility in pure water. Microencapsulation or solvent system is commonly adopted in cosmetic and supplement formulations.
Q4: Can I get trial samples of Nobiletin for quality verification?
A4: We provide small quantity samples for lab testing. Customers need to cover the shipping cost. Reach out to our sales to confirm available sample specifications.
Q5: How to store Nobiletin to retain quality?
A5: Keep the container tightly sealed, store in cool, dry and dark environment. For long-term preservation, store at -20°C. Avoid frequent exposure to air, high temperature and strong ultraviolet light.
Q6: What package sizes can you supply for Nobiletin?
A6: We offer lab scale packages (1g,5g,10g,100g) and bulk industrial packages (1kg foil bag, 25kg drum). Custom packing specifications are acceptable.
Q7: Can this Nobiletin powder be consumed directly?
A7: Our Nobiletin raw powder is solely for research and further formulation processing. It cannot be directly ingested without professional formula development.
Q8: What certification documents can you offer for export?
A8: We can provide COA, HPLC chromatogram, SDS, commercial invoice, packing list and Certificate of Origin. Extra documents can be arranged according to your local import regulations.
Fixed Disclaimer
Send inquiry or contact us to get free sample, and learn more details about it.
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