+8615291419866
video

Sinensetin | Pentamethoxyflavone CAS 2306-27-6 Natural Citrus Polymethoxyflavone Powder

Common Name: Sinensetin
Systematic Name: 2-(3,4-Dimethoxyphenyl)-5,6,7-trimethoxy-4H-chromen-4-one
Synonym: Pentamethoxyflavone, Pedalitin permethyl ether
CAS Number: 2306-27-6
Molecular Formula: C₂₀H₂₀O₇
Molecular Weight: 372.37
Appearance: Off-white to light yellow crystalline powder
Solubility: Soluble in DMSO, ethanol, methanol; slightly soluble in neutral aqueous solution
Source: Citrus peel extract / Synthetic

Description

 

Brief Introduction

 

Sinensetin is a naturally occurring polymethoxylated flavone mainly accumulated in citrus peels and Orthosiphon aristatus. Chemically named Pentamethoxyflavone, it features five methoxy substitutions on the flavone backbone. Compared with common flavonoids, this permethylated structure delivers improved lipophilicity and membrane permeability, making it a high-value bioactive phytochemical for cosmetic actives, dietary supplement research and pharmaceutical intermediate study.

Our Sinensetin adopts standardized purification technology from citrus raw materials. Strict HPLC testing ensures stable purity, low heavy metal residues and consistent batch-to-batch quality to satisfy industrial formulation and laboratory research demands.

 

 

Core Biological Properties

 

 

 

Scientific researches confirm Sinensetin owns multiple valuable bioactivities:

  • Powerful antioxidant capacity to neutralize excess free radicals
  • Regulates inflammatory mediators and exhibits anti-inflammatory effects
  • Supports lipid metabolism and shows anti-adipogenic potential
  • Acts as P-glycoprotein inhibitor, helps improve cellular absorption of co-formulated ingredients
  • Displays mild antimicrobial activity against multiple strains
  • Shows neuroprotective and hepatoprotective effects in in-vitro models
 

Industrial Application Fields

 

 

✅ Cosmetic Raw Materials

Applied in anti-aging, soothing and brightening skincare formulas. Its antioxidant property reduces oxidative stress on skin cells and relieves mild inflammatory discomfort.

✅ Nutraceutical & Dietary Supplement Research

Used in formula development targeting metabolic balance and antioxidant support.

✅ Pharmaceutical & Laboratory Research

Serves as reference standard, research tool compound for flavonoid pharmacology, cell mechanism and anti-proliferation studies.

✅ Plant Extract Compound Formulation

Combined with Nobiletin, Tangeretin and other citrus polymethoxyflavones for synergistic activity

 

Specification List

  • Purity: ≥98% HPLC / ≥99% HPLC (customizable)
  • Loss on Drying: ≤0.5%
  • Heavy Metals: Pb<10ppm, As<2ppm, Cd<1ppm, Hg<1ppm
  • Residual Solvents: Meet ICH Q3C limits
  • Microbe: Total aerobic count <1000 CFU/g; Yeast & Mold <100 CFU/g
  • Storage Condition: Sealed, cool and dry place, avoid direct light; -20℃ for long-term preservation
  • Shelf Life: 24 months under proper storage
 

Packaging & Shipment

 

 

 

Fmoc Series Protected Amino Acids

01.Packaging and service
  • Lab sample: 10g, 100g aluminum foil vacuum bag
  • Industrial bulk: 25kg fiber drum with double PE inner bag
  • Sea FOB shipping for large batch orders, air express for small trial samples
02.Delivery Methods

1.Express Delivery
3-5 days for shipments under 100 kg
Door-to-door service

2.Ocean Freight
Over 300 kg: Approximately 30 days. Port-to-port service requires a professional customs clearance agent.

3.Air Freight
100kg-1000kg, 5-7 days
Airport-to-airport service, requires a professional customs clearance agent

Fmoc Series Protected Amino Acids

 

OEM & Custom Service

 

We provide flexible one-stop OEM and customization solutions for Sinensetin to satisfy diverse laboratory, cosmetic and nutraceutical formulation demands.

  • Customized purity specification: 98% HPLC, 99% HPLC and other customized content standards available
  • Custom processing service: Fine pulverization, mixing with other citrus polymethoxyflavones such as Nobiletin and Tangeretin
  • Custom packaging: Label design, private label, small trial packages and industrial bulk drum packing
  • Custom testing service: Additional testing items including residual solvent, microorganism and heavy metal testing according to client requirements
  • Custom documentation: Tailored COA, SDS, technical datasheet meeting different regional import standards All customization projects support sample pre-verification before mass production. Please send your detailed technical indicators and packaging requirements to our sales team for a targeted quotation.

 

 

Why Choose Xi'an Dowell Healthy Sinensetin?

 

 

  • Reliable stable supply: We maintain continuous inventory of high-purity Sinensetin, supporting small trial orders and large-scale bulk shipments globally
  • Strict quality control system: Every batch undergoes HPLC inspection, complete test records and traceable raw material sources
  • Professional technical support: Our R&D team offers technical consultation regarding solubility, formulation compatibility and application schemes of Sinensetin
  • Competitive factory direct price: No middlemen markup, transparent pricing for both research samples and industrial bulk orders
  • Complete export documents: We can supply COA, SDS, NMR, HPLC spectrum and customs clearance certificates for worldwide shipping
  • Flexible logistics solutions: Support air freight, sea freight and express delivery, with reasonable packaging to prevent product deterioration during transit
  • Confidential cooperation guarantee: We strictly protect clients' formulation formulas, customization demands and business information
 

Frequently Asked Questions

Q1: What is Sinensetin used for?

A1: Sinensetin is a natural polymethoxyflavone extracted mainly from citrus peels. It is widely used as raw material for cosmetic research, nutraceutical formula development and pharmacological cell study, valued for antioxidant and anti-inflammatory related properties.

Q2: What is the CAS number of Sinensetin?

A2: The CAS registry number of Sinensetin is 2306-27-6, with chemical name 5,6,7,3',4'-Pentamethoxyflavone.

Q3: What is the solubility of Sinensetin powder?

A3: Sinensetin dissolves well in ethanol, methanol and DMSO. It shows poor solubility in pure water. Cosmetic and lab applications usually adopt solvent-assisted dissolution or microencapsulation technology.

Q4: Can I get free Sinensetin samples for testing?

A4: We provide small quantity trial samples for quality evaluation. Sample freight cost needs to be undertaken by customers. You can contact our sales to confirm available sample specifications.

Q5: How should I store Sinensetin to extend shelf life?

A5: Please seal the product tightly, store in cool, dry and dark environment. Long-term storage is recommended at -20°C. Avoid repeated exposure to air, high temperature and strong sunlight.

Q6: What packing sizes of Sinensetin can you offer?

A6: We supply lab-scale packages (1g, 5g, 10g, 100g) and bulk industrial packages (1kg aluminum foil bag, 25kg fiber drum). Custom packing is acceptable.

Q7: Is Sinensetin suitable for direct oral consumption?

A7: Our Sinensetin raw powder is only for research use or further formulation development. It cannot be directly taken orally without professional formula development.

Q8: What documents can you provide for customs clearance?

A8: We can provide COA, HPLC chromatogram, SDS, commercial invoice, packing list and certificate of origin. Extra documents can be arranged according to your country's import regulations.

Fixed Disclaimer

Disclaimer: All pharmaceutical intermediates provided by Dowell Ingredients are exclusively for laboratory research and pharmaceutical synthetic R&D use. Finished controlled APIs are not available for direct sales. Formal enterprise qualification review is required prior to quotation and bulk order arrangement.
modular-1
Send inquiry or contact us to get free sample, and learn more details about it.

Hot Tags: Sinensetin | Pentamethoxyflavone CAS 2306-27-6 Natural Citrus Polymethoxyflavone Powder, China Sinensetin | Pentamethoxyflavone CAS 2306-27-6 Natural Citrus Polymethoxyflavone Powder manufacturers, suppliers, factory

Contact Supplier