Product Overview

Vitamin B1 is a water-soluble vitamin used as a coenzyme in carbohydrate metabolism and energy-related biochemical processes.

Technical Specifications

Parameter Category	Technical Parameter	Specification 1 (Food/Feed Grade)	Specification 2 (Pharma Grade)
Product Information	Product Name	Vitamin B1	Vitamin B1
	Available Forms	Thiamine Mononitrate (Nitrate Salt)	Thiamine Hydrochloride (HCl Salt)
	Active B1 Content	~91.8%	~78.5%
Physical Properties	Appearance	White to light yellowish crystalline powder	White or almost white crystalline powder
	Solubility (20°C)	Sparingly soluble in water (~2.7 g/100 mL)	Freely soluble in water (~1 g/1 mL)
	Hygroscopicity	Non-hygroscopic (Stable in air)	Highly hygroscopic (Absorbs moisture)
	Melting Point	~196°C – 200°C (with decomposition)	~248°C (with decomposition)
	Bulk Density	0.35 – 0.55 g/mL	0.25 – 0.40 g/mL
Chemical & Purity	Assay (Dry Basis)	98.0% – 102.0%	98.5% – 101.5%
	pH Value	6.0 – 7.5 (2% aqueous suspension)	2.7 – 3.4 (2.5% aqueous solution)
	Loss on Drying	≤1.0%	≤5.0%
	Residue on Ignition	≤0.2%	≤0.2%
	Total Impurities	≤1.0%	≤1.0%
Heavy Metals	Lead (Pb)	≤2 ppm	≤2 ppm
	Arsenic (As)	≤1 ppm	≤1 ppm
	Total Heavy Metals	≤10 ppm	≤10 ppm
Microbiological	Total Aerobic Count	≤1,000 cfu/g	≤1,000 cfu/g
	Yeasts & Moulds	≤100 cfu/g	≤100 cfu/g
	E. coli / Salmonella	Negative	Negative
Compliance	Standard	FCC / USP / Feed Grade	USP / EP / BP / ChP / GMP

Salt-Specific Moisture Control

Thiamine Mononitrate moisture is controlled at ≤1.0% according to product specifications.

Precision pH Regulation

Aqueous pH is maintained within 2.7–3.4 for process control purposes.

Thiamine-Specific Purity Assurance

HPLC testing verifies total related substances at ≤1.0% for specification compliance.

Solution Clarity Verification

Absorbance values are maintained at ≤0.025, confirming solution clarity requirements.

Light-Resistant Packaging

Multi-layer aluminum foil bags provide light protection during storage and transport.

Moisture-Proof Drum Sealing

Sealed high-density drums are used to reduce moisture exposure.

Temperature-Controlled Logistics

Shipping below 25°C is recommended during transportation.

Vacuum-Sealed Inner Liners

Oxygen-barrier liners are used to reduce oxygen exposure during storage.

Pharmacopoeia Compliance: Regulatory dossiers are prepared with reference to USP, EP, BP, and ChP thiamine monographs.

Process Impurity Statements: Statements document the control of pyrimidine and thiazole-related process materials.

Salt-Specific BSE/TSE Statements: Official statements verify that crystallization processes for Vitamin B1 utilize non-animal materials.

Residual Solvents Control: GC-MS reports verify that crystallization solvents meet strict ICH limits.

Application Field	How It Is Used
Pharmaceuticals	Used in the manufacture of thiamine-containing injections, tablets, capsules, and oral liquid formulations.
Dietary Supplements	Incorporated into multivitamin products, B-complex supplements, capsules, tablets, and nutritional premixes.
Food & Beverages	Added to fortified flour, cereals, bakery products, beverages, and functional foods.
Animal Nutrition	Included in premixes, aquaculture feed, livestock feed, and companion animal nutrition products.

Q: How is temperature controlled during the milling of Vitamin B1?

A: Milling lines utilize air-cooling systems to control processing temperatures.

Q: Can the factory provide batch-specific particle size distributions for Vitamin B1?

A: Yes, laser diffraction grain-size analysis charts are supplied to ensure compatibility with varied customer blending equipment.

Q: How does the factory ensure no cross-contamination between different grades of Vitamin B1?

A: Separate, dedicated synthesis lines and isolated cleanrooms are utilized for pharmaceutical and feed-grade production runs.

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