Products Description
Riboflavin is a water-soluble vitamin used in food, feed, supplement, and pharmaceutical applications.
Technical Specifications
|
Parameter Category |
Technical Item |
Standard Specification / Description |
|
Physical Properties |
Appearance |
Yellow to orange-yellow crystalline powder |
|
Odor & Taste |
Slight characteristic odor, slightly bitter taste |
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|
Melting Point |
Approx. 280°C–290°C (with decomposition) |
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|
Specific Rotation [α]D20 |
−115° to −135° (c=0.5%, in 0.05 mol/L NaOH) |
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|
Loss on Drying |
≤1.5% |
|
|
Residue on Ignition (Ash) |
≤0.1% |
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Solution & Optical Properties |
pH of Saturated Aqueous Solution (20°C) |
5.5–7.2 |
|
Dissociation Constant (pKa) |
1.7 (weakly acidic) / 9.69 (weakly basic) |
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|
Absorption Maxima (λmax) |
268 nm, 373 nm, 444 nm (aqueous solution) |
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Fluorescence |
Dilute aqueous solution appears pale yellow; shows yellow-green fluorescence under transmitted light |
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|
Solubility (25°C) |
Water |
Very slightly soluble (approx. 0.07–0.13 g/L, crystal-form dependent) |
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Dilute Alkaline Solutions |
Sparingly soluble, but undergoes rapid chemical degradation |
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Organic Solvents |
Practically insoluble in ethanol, diethyl ether, chloroform, and acetone |
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Stability & Incompatibilities |
Light Sensitivity |
Susceptible to photolysis in solution; alkaline conditions accelerate degradation; solid form relatively stable under scattered light |
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Thermal Stability |
Stable in acidic conditions (pH < 6.0) when protected from light; degrades under alkaline heating conditions |
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Incompatibilities |
Strong oxidizing agents, reducing agents, heavy metal salts, alkaline substances, calcium-containing compounds |
Regulatory & Quality Certifications
Pharmacopoeia Compliance: Complies with current USP, EP, and BP monograph requirements for Riboflavin.
Fermentation Process Validation: Produced through microbial fermentation using documented production strains.
Residual Solvents Control: Complies with ICH Q3C guidelines regarding organic solvents used during Riboflavin purification.
Feed Additive Approval: Holds valid FAMI-QS certification for international animal nutrition and feed-grade distribution.
USP-NF / FCC Grade: Available for pharmaceutical and food-additive applications.
TSE/BSE Free: Manufactured without animal-derived raw materials and supported by TSE/BSE statements.
E-Number Compliance: Documented adherence to European food additive criteria designated under code E101.
Manufacturing Facility & Capacity
Dedicated Fermentation Lines
Equipped with automated bioreactors for Riboflavin fermentation processes.
Closed-Loop Purification
Features dedicated crystallization and drying systems with cross-contamination control procedures.
Scalable Annual Output
Annual output capacity meets commercial-scale food, feed, and pharmaceutical demands.
Cleanroom Packaging Environment
Final milling and packaging operations conducted within designated Grade D (ISO 8) cleanrooms.
DCS Process Control
Utilizes Distributed Control Systems to monitor temperature and aeration parameters.
Sustained Raw Material Supply
Integrated procurement systems support substrate availability for fermentation production.
Quality Control & Traceability
|
Testing Method / Parameter |
Quality Evidence & Analysis |
|
High-Performance Liquid Chromatography (HPLC) |
Riboflavin assay indicates purity complies with standards (≥98.0%). |
|
Microbial Limit Testing |
Total aerobic microbial count (TAMC) is limited to ≤1,000 CFU/g. |
|
Heavy Metal Monitoring |
ICP testing shows lead and arsenic levels below 1 ppm. |
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Lumiflavin Impurity Control |
Spectrophotometric absorbance testing monitors lumiflavin-related impurities. |
|
Particle Size Distribution |
Laser diffraction confirms consistent particle size distribution and mesh uniformity. |
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Controlled Loss on Drying |
Moisture level maintained below 1.5% according to product specifications. |
FAQ
Q: What standard container configuration is utilized to protect Riboflavin from moisture during sea transit?
A: Riboflavin is packed in heavy-duty fiber drums lined with dual-layer, moisture-resistant polyethylene bags.
Q: How does the packaging line safeguard Riboflavin against light-induced degradation before shipping?
A: Filling operations use light-shielding packaging materials to reduce light exposure during storage.
Q: What specific container conditions are required for shipping Riboflavin through high-humidity tropical routes?
A: Shipments may utilize desiccant packs within sealed ocean containers to control humidity levels.
Q: What is the recommended pallet stacking limit to prevent product caking during warehouse storage?
A: Pallets are restricted to a maximum of two tiers to prevent compaction pressure on lower drums.
Q: How is batch segregation maintained during multi-ton bulk shipments of Riboflavin?
A: Every pallet carries unique, line-scanned barcodes linked to a central ERP system for precise traceability.
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